ZFIN ID: ZDB-GENE-040718-423
Gene Name: deoxyribonuclease I
Gene Symbol: dnase1    Nomenclature History

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Previous Name: zgc:92440 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have DNA binding activity and deoxyribonuclease I activity. Predicted to be involved in DNA catabolic process, endonucleolytic. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to several human genes including DNASE1 (deoxyribonuclease 1).
Genome Resources: Alliance (1),  Gene:436947 (1),  Ensembl(GRCz11):ENSDARG00000012539 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92440]
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024070Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40076 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dnase1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    systemic lupus erythematosus Alliance {Systemic lupus erythematosus, susceptibility to} 152700
    DISEASE ASSOCIATED WITH dnase1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process DNA catabolic process (more)
    Cellular Component nucleus (more)
    Molecular Function deoxyribonuclease activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dnase1-201 (1)    Ensembl 1309
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dnase1 No data available
    MARKER RELATIONSHIPS
    dnase1 Contained in: [BAC] CH211-287C12 (1)
    dnase1 Encodes: [cDNA] MGC:92440 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002674 (1) 1270 nt
    Genomic GenBank:BX936335 (1) 62086 nt
    Select Tool
    Polypeptide UniProtKB:Q6DG72 (1) 278 aa
    Sequence Information (all 8)
    ORTHOLOGY for dnase1 ( Chr: 3 )
    CITATIONS (23)