ZFIN ID: ZDB-GENE-040718-419
Gene Name: crystallin, alpha B, b
Gene Symbol: cryabb    Nomenclature History

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Previous Names: cryab2, fe37f08, hspb5b (1), wu:fe37f08, zgc:91937

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Exhibits unfolded protein binding activity. Involved in several processes, including heart contraction; myofibril assembly; and skeletal muscle tissue development. Is expressed in several structures, including brain; heart; lens; liver; and otic vesicle. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAB (crystallin alpha B).
Genome Resources: Alliance (1),  Gene:436943 (1),  Ensembl(GRCz11):ENSDARG00000101380 (1)
GENE EXPRESSION
All Expression Data: 15 figures from 14 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:91937]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa33728 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vu613 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-cryabb 1
    CRISPR2-cryabb 1
    CRISPR3-cryabb 1
    CRISPR4-cryabb 1
    CRISPR5-cryabb
    1
    MO1-cryabb N/A 1
    MO2-cryabb N/A 1
    DISEASE ASSOCIATED WITH cryabb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cataract 16 multiple types Alliance Cataract 16, multiple types 613763
    dilated cardiomyopathy 1II Alliance Cardiomyopathy, dilated, 1II 615184
    fatal infantile hypertonic myofibrillar myopathy Alliance Myopathy, myofibrillar, fatal infantile hypertonic, alpha-B crystallin-related 613869
    myofibrillar myopathy 2 Alliance Myopathy, myofibrillar, 2 608810
    DISEASE ASSOCIATED WITH cryabb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart contraction (more)
    Cellular Component cellular_component (more)
    Molecular Function unfolded protein binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cryabb-201 (1)    Ensembl 1003
    cryabb-202 (1)    Ensembl 952
    cryabb-203 (1)    Ensembl 2192
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM cryabb
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(cryaa:cryabb,myl7:TagRFP) cryaamyl7 cryabbTagRFP Danio rerio 1 1
    MARKER RELATIONSHIPS
    cryabb Contained in: [BAC] CH73-128B20 (1), CH211-202F5 (1)
    cryabb Encodes: [EST] fe37f08
    [cDNA] MGC:91937 (1), MGC:191143 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002670 (1) 2192 nt
    Genomic GenBank:BX510338 (1) 87819 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IG31 (1) 180 aa
    Sequence Information (all 27)
    ORTHOLOGY for cryabb ( Chr: 5 )
    CITATIONS (39)