ZFIN ID: ZDB-GENE-040718-393
Gene Name: adenosine deaminase
Gene Symbol: ada    Nomenclature History

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Previous Names: ada1 (1), zgc:92028

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Exhibits adenosine deaminase activity. Predicted to be involved in T cell activation; negative regulation of adenosine receptor signaling pathway; and nucleobase-containing small molecule metabolic process. Predicted to localize to cytosol and external side of plasma membrane. Is expressed in several structures, including digestive system; gill; heart; kidney; and muscle. Human ortholog(s) of this gene implicated in adenosine deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (adenosine deaminase).
Genome Resources: Alliance (1),  Gene:436919 (1),  Ensembl(GRCz11):ENSDARG00000003113 (2)
GENE EXPRESSION
All Expression Data: 8 figures from 6 publications
Directly Submitted Expression Data: 3 figures (2 images) from Thisse et al., 2004 [IMAGE:6911877]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa37719 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ada HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    adenosine deaminase deficiency Alliance Adenosine deaminase deficiency, partial 102700
    Severe combined immunodeficiency due to ADA deficiency 102700
    DISEASE ASSOCIATED WITH ada VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process adenosine catabolic process (more)
    Cellular Component cell junction (more)
    Molecular Function adenosine deaminase activity (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ada-201 (1)    Ensembl 2321
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ada No data available
    MARKER RELATIONSHIPS
    ada Contained in: [BAC] DKEY-51B3 (1) (order this), DKEY-254E8 (1) (order this)
    ada Encodes: [EST] IMAGE:6911877 (1)
    [cDNA] MGC:92028 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002646 (1) 2340 nt
    Genomic GenBank:CR678304 (1) 79195 nt
    Select Tool
    Polypeptide UniProtKB:F1RA33 (1) 362 aa
    Sequence Information (all 13)
    ORTHOLOGY for ada ( Chr: 23 )
    CITATIONS (44)