Gene

ada

ID
ZDB-GENE-040718-393
Name
adenosine deaminase
Symbol
ada Nomenclature History
Previous Names
  • ada1 (1)
  • zgc:92028
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Exhibits adenosine deaminase activity. Predicted to be involved in T cell activation; negative regulation of adenosine receptor signaling pathway; and nucleobase-containing small molecule metabolic process. Predicted to localize to cytosol and external side of plasma membrane. Is expressed in several structures, including digestive system; gill; heart; kidney; and muscle. Human ortholog(s) of this gene implicated in adenosine deaminase deficiency; asthma; and severe combined immunodeficiency. Orthologous to human ADA (adenosine deaminase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 6 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ada Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
adenosine deaminase deficiency Alliance Adenosine deaminase deficiency, partial 102700
adenosine deaminase deficiency Alliance Severe combined immunodeficiency due to ADA deficiency 102700
Associated With ada Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR006650 Adenosine/AMP deaminase active site
Domain IPR001365 Adenosine/AMP deaminase domain
Family IPR006330 Adenosine/adenine deaminase
Family IPR028893 Adenosine deaminase
Homologous_superfamily IPR032466 Metal-dependent hydrolase
Domain Details Per Protein
Protein Length Adenosine/adenine deaminase Adenosine/AMP deaminase active site Adenosine/AMP deaminase domain Adenosine deaminase Metal-dependent hydrolase
UniProtKB:F1RA33 362
UniProtKB:Q6DG22 359
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations