ZFIN ID: ZDB-GENE-040718-36
Gene Name: hydrogen voltage-gated channel 1
Gene Symbol: hvcn1    Nomenclature History

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Previous Name: zgc:92181 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits voltage-gated proton channel activity and zinc ion binding activity. Involved in proton transmembrane transport and response to zinc ion. Localizes to integral component of plasma membrane. Is expressed in several structures, including eye; heart; liver; neutrophil; and pleuroperitoneal region. Orthologous to human HVCN1 (hydrogen voltage gated channel 1).
Genome Resources: Alliance (1),  Gene:436618 (1),  Ensembl(GRCz11):ENSDARG00000040338 (2)
GENE EXPRESSION
All Expression Data: Fig. 3 from Ratanayotha et al., 2017
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ou1001 Indel Unknown Unknown CRISPR
sa41591 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hvcn1 1
    CRISPR2-hvcn1
    1
    CRISPR3-hvcn1
    1
    CRISPR4-hvcn1
    1
    DISEASE ASSOCIATED WITH hvcn1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hvcn1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proton transmembrane transport (more)
    Cellular Component integral component of plasma membrane (more)
    Molecular Function voltage-gated proton channel activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hvcn1-201 (1)    Ensembl 1363
    ncRNA hvcn1-002 (1)    Ensembl 554
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hvcn1 No data available
    MARKER RELATIONSHIPS
    hvcn1 Contained in: [BAC] CH73-329B8 (1)
    hvcn1 Encodes: [cDNA] MGC:92181 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002346 (1) 1254 nt
    Genomic GenBank:CU682363 (1) 121742 nt
    Select Tool
    Polypeptide UniProtKB:F1QS97 (1) 235 aa
    Sequence Information (all 11)
    ORTHOLOGY for hvcn1 ( Chr: 10 )
    CITATIONS (21)