Gene

egln1b

ID
ZDB-GENE-040718-338
Name
egl-9 family hypoxia-inducible factor 1b
Symbol
egln1b Nomenclature History
Previous Names
  • egln1
  • fk45e02
  • Hif-p4h-2 (1)
  • wu:fk45e02
  • zgc:92314 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to have ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Predicted to be involved in cellular response to hypoxia and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With egln1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial erythrocytosis 3 Alliance Erythrocytosis, familial, 3 609820
[Hemoglobin, high altitude adaptation] 609070
Associated With egln1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002893 Zinc finger, MYND-type
Domain IPR005123 Oxoglutarate/iron-dependent dioxygenase
Domain IPR006620 Prolyl 4-hydroxylase, alpha subunit
Domain Details Per Protein
Protein Length Oxoglutarate/iron-dependent dioxygenase Prolyl 4-hydroxylase, alpha subunit Zinc finger, MYND-type
UniProtKB:Q6DHH3 335
UniProtKB:F1Q5G1 232
UniProtKB:F6P6J7 358
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations