Gene

egln1b

ID
ZDB-GENE-040718-338
Name
egl-9 family hypoxia-inducible factor 1b
Symbol
egln1b Nomenclature History
Previous Names
  • egln1
  • fk45e02
  • Hif-p4h-2 (1)
  • wu:fk45e02
  • zgc:92314 (1)
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable ferrous iron binding activity and peptidyl-proline 4-dioxygenase activity. Predicted to be involved in cellular response to hypoxia and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in familial erythrocytosis 3; polycythemia; and renal cell carcinoma. Orthologous to human EGLN1 (egl-9 family hypoxia inducible factor 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With egln1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial erythrocytosis 3 Alliance Erythrocytosis, familial, 3 609820
[Hemoglobin, high altitude adaptation] 609070
Associated With egln1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002893 Zinc finger, MYND-type
Domain IPR005123 Oxoglutarate/iron-dependent dioxygenase
Domain IPR006620 Prolyl 4-hydroxylase, alpha subunit
Domain IPR044862 Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Domain Details Per Protein
Protein Length Oxoglutarate/iron-dependent dioxygenase Prolyl 4-hydroxylase, alpha subunit Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain Zinc finger, MYND-type
UniProtKB:F6P6J7 358
UniProtKB:Q6DHH3 335
UniProtKB:F1Q5G1 232
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations