ZFIN ID: ZDB-GENE-040718-328
Gene Name: SEC63 homolog, protein translocation regulator
Gene Symbol: sec63    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: zgc:92718

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have RNA binding activity and protein transmembrane transporter activity. Involved in endoplasmic reticulum unfolded protein response; liver development; and myelination. Predicted to localize to Sec62/Sec63 complex. Used to study fatty liver disease and polycystic liver disease. Human ortholog(s) of this gene implicated in polycystic liver disease. Orthologous to human SEC63 (SEC63 homolog, protein translocation regulator).
Genome Resources: Alliance (1),  Gene:436861 (1),  Ensembl(GRCz11):ENSDARG00000017740 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7151132]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12378 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37078 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • st67 Point Mutation Unknown Missense ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-sec63 N/A 2
    DISEASE ASSOCIATED WITH sec63 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Polycystic liver disease 2 617004
    DISEASE ASSOCIATED WITH sec63 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    fatty liver disease sec63st67/st67 standard conditions (2)
    polycystic liver disease WT + MO1-sec63 standard conditions Tietz Bogert et al., 2013
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endoplasmic reticulum unfolded protein response (more)
    Cellular Component integral component of membrane (more)
    Molecular Function protein transmembrane transporter activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sec63-201 (1)    Ensembl 4207
    sec63-204 (1)    Ensembl 4207
    ncRNA sec63-002 (1)    Ensembl 601
    sec63-003 (1)    Ensembl 753
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sec63 No data available
    MARKER RELATIONSHIPS
    sec63 Contained in: [BAC] CH73-257C13 (1)
    [Fosmid] CH1073-83O12 (1), CH1073-108O16 (1)
    sec63 Encodes: [EST] IMAGE:7151132 (1)
    [cDNA] MGC:92718 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002588 (1) 2690 nt
    Genomic GenBank:CU207298 (1) 34410 nt
    Select Tool
    Polypeptide UniProtKB:F1QGI2 (1) 751 aa
    Sequence Information (all 13)
    ORTHOLOGY for sec63 ( Chr: 20 )
    CITATIONS (26)