Gene

clic2

ID
ZDB-GENE-040718-299
Name
chloride intracellular channel 2
Symbol
clic2 Nomenclature History
Previous Names
  • zgc:92762
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have chloride channel activity. Predicted to be involved in chloride transport and regulation of ion transmembrane transport. Predicted to localize to nucleus. Is expressed in several structures, including blood; cardiovascular system; macrophage; mesoderm; and neuromast. Human ortholog(s) of this gene implicated in X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome. Orthologous to human CLIC2 (chloride intracellular channel 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
8 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With clic2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
X-linked intellectual disability-cardiomegaly-congestive heart failure syndrome Alliance ?Mental retardation, X-linked, syndromic 32 300886
Associated With clic2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004045 Glutathione S-transferase, N-terminal
Domain IPR010987 Glutathione S-transferase, C-terminal-like
Family IPR002946 Intracellular chloride channel
Family IPR040079 Glutathione Transferase family
Homologous_superfamily IPR036249 Thioredoxin-like superfamily
Homologous_superfamily IPR036282 Glutathione S-transferase, C-terminal domain superfamily
Domain Details Per Protein
Protein Length Glutathione S-transferase, C-terminal domain superfamily Glutathione S-transferase, C-terminal-like Glutathione S-transferase, N-terminal Glutathione Transferase family Intracellular chloride channel Thioredoxin-like superfamily
UniProtKB:Q6DGV0 239
UniProtKB:F1QTI1 239
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations