ZFIN is now using GRCz12tu for Genomic Data
Gene
pnpla3
- ID
- ZDB-GENE-040718-27
- Name
- patatin-like phospholipase domain containing 3
- Symbol
- pnpla3 Nomenclature History
- Previous Names
-
- zgc:92195
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable triacylglycerol lipase activity. Acts upstream of or within liver development. Predicted to be active in cytoplasm; lipid droplet; and membrane. Human ortholog(s) of this gene implicated in coronary artery disease; liver disease (multiple); and type 2 diabetes mellitus. Orthologous to human PNPLA3 (patatin like phospholipase domain containing 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Dinarello et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Acyl transferase/acyl hydrolase/lysophospholipase | Patatin-like phospholipase domain | Patatin-like phospholipase domain-containing protein | Patatin-like phospholipase domain-containing protein 2 |
|---|---|---|---|---|---|---|
| UniProtKB:Q6DHN9 | InterPro | 473 | ||||
| UniProtKB:A0AB32TQQ9 | InterPro | 473 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
pnpla3-201
(1)
|
Ensembl | 1,891 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers