ZFIN ID: ZDB-GENE-040718-245
Gene Name: inositol monophosphatase 1
Gene Symbol: impa1    Nomenclature History

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Previous Name: zgc:100926

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have inositol monophosphate 1-phosphatase activity. Predicted to be involved in inositol metabolic process; inositol phosphate dephosphorylation; and signal transduction. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human IMPA1 (inositol monophosphatase 1).
Genome Resources: Alliance (1),  Gene:437018 (1),  Ensembl(GRCz11):ENSDARG00000003517 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7145589]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7262 Point Mutation Unknown Splice Site ENU
sa31280 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH impa1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mental retardation, autosomal recessive 59 617323
    DISEASE ASSOCIATED WITH impa1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process inositol biosynthetic process (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA impa1-201 (1)    Ensembl 1314
    impa1-202 (1)    Ensembl 965
    impa1-203 (1)    Ensembl 300
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM impa1 No data available
    MARKER RELATIONSHIPS
    impa1 Contained in: [BAC] DKEY-181M9 (1) (order this)
    impa1 Encodes: [EST] IMAGE:7145589 (1)
    [cDNA] MGC:100926 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002745 (1) 1310 nt
    Genomic GenBank:BX248497 (1) 145610 nt
    Select Tool
    Polypeptide UniProtKB:Q6DGB2 (1) 282 aa
    Sequence Information (all 15)
    ORTHOLOGY for impa1 ( Chr: 2 )
    CITATIONS (25)