Gene

impa1

ID
ZDB-GENE-040718-245
Name
inositol monophosphatase 1
Symbol
impa1 Nomenclature History
Previous Names
  • zgc:100926
Type
protein_coding_gene
Location
Chr: 2 Mapping Details/Browsers
Description
Predicted to enable inositol monophosphate 1-phosphatase activity. Predicted to be involved in inositol metabolic process; inositol phosphate dephosphorylation; and signal transduction. Predicted to act upstream of or within phosphatidylinositol phosphate biosynthetic process. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human IMPA1 (inositol monophosphatase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With impa1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mental retardation, autosomal recessive 59 617323
Associated With impa1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR020583 Inositol monophosphatase, metal-binding site
Conserved_site IPR020550 Inositol monophosphatase, conserved site
Family IPR000760 Inositol monophosphatase-like
Family IPR020552 Inositol monophosphatase, lithium-sensitive
Family IPR033942 Inositol monophosphatase
Domain Details Per Protein
Protein Length Inositol monophosphatase Inositol monophosphatase, conserved site Inositol monophosphatase-like Inositol monophosphatase, lithium-sensitive Inositol monophosphatase, metal-binding site
UniProtKB:Q6DGB2 282
UniProtKB:B0S5J9 239
UniProtKB:B0S5J8 19
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations