ZFIN ID: ZDB-GENE-040718-174
Gene Name: ATPase plasma membrane Ca2+ transporting 3a
Gene Symbol: atp2b3a    Nomenclature History

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Previous Names: atp2b3, pmca3a (1), zgc:92885 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have PDZ domain binding activity and calcium transmembrane transporter activity, phosphorylative mechanism. Predicted to be involved in regulation of cytosolic calcium ion concentration. Predicted to localize to intracellular membrane-bounded organelle. Is expressed in blood; liver; muscle; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in X-linked spinocerebellar ataxia 1. Orthologous to human ATP2B3 (ATPase plasma membrane Ca2+ transporting 3).
Genome Resources: Alliance (1),  Gene:436745 (1),  Ensembl(GRCz11):ENSDARG00000043474 (1)
GENE EXPRESSION
All Expression Data: 8 figures from 3 publications
Directly Submitted Expression Data: 6 figures (8 images) from Thisse et al., 2004 [MGC:92885]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016259Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2421 Point Mutation Unknown Premature Stop ENU
    sa10745 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18912 Point Mutation Unknown Splice Site ENU
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH atp2b3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    X-linked spinocerebellar ataxia 1 Alliance ?Spinocerebellar ataxia, X-linked 1 302500
    DISEASE ASSOCIATED WITH atp2b3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion transmembrane transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atp2b3a-201 (1)    Ensembl 3635
    atp2b3a-202 (1)    Ensembl 901
    atp2b3a-203 (1)    Ensembl 4671
    ncRNA atp2b3a-003 (1)    Ensembl 756
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atp2b3a No data available
    MARKER RELATIONSHIPS
    atp2b3a Contained in: [BAC] CH211-229N2 (1), DKEYP-110G5 (1)
    atp2b3a Encodes: [cDNA] MGC:92885 (1)
    atp2b3a Has Artifact: [EST] fk54d07
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002472 (1) 2539 nt
    Genomic GenBank:CT025854 (1) 184858 nt
    Select Tool
    Polypeptide UniProtKB:B0S5H3 (1) 1248 aa
    Sequence Information (all 30)
    ORTHOLOGY for atp2b3a ( Chr: 8 )
    CITATIONS (31)