ZFIN ID: ZDB-GENE-040718-16
Gene Name: alanine--glyoxylate and serine--pyruvate aminotransferase a
Gene Symbol: agxta    Nomenclature History

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Previous Names: agxtl, zgc:91879

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have alanine-glyoxylate transaminase activity and serine-pyruvate transaminase activity. Predicted to be involved in glycine biosynthetic process, by transamination of glyoxylate. Predicted to localize to peroxisome. Is expressed in liver and pronephric duct. Human ortholog(s) of this gene implicated in primary hyperoxaluria type 1. Orthologous to human AGXT (alanine--glyoxylate and serine--pyruvate aminotransferase).
Genome Resources: Alliance (1),  Gene:436603 (1),  Ensembl(GRCz11):ENSDARG00000052099 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 7 figures (8 images) from Thisse et al., 2004 [MGC:91879]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa7041 Point Mutation Unknown Splice Site ENU
sa26748 Point Mutation Unknown Splice Site ENU
sa33871 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH agxta HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    primary hyperoxaluria type 1 Alliance Hyperoxaluria, primary, type 1 259900
    DISEASE ASSOCIATED WITH agxta VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process glycine biosynthetic process, by transamination of glyoxylate (more)
    Cellular Component peroxisome (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA agxta-201 (1)    Ensembl 1394
    ncRNA agxta-002 (1)    Ensembl 915
    agxta-003 (1)    Ensembl 672
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM agxta No data available
    MARKER RELATIONSHIPS
    agxta Contained in: [BAC] DKEY-107H14 (1) (order this)
    agxta Encodes: [cDNA] MGC:91879 (1), MGC:191887 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002331 (1) 1395 nt
    Genomic GenBank:CU467043 (1) 135926 nt
    Select Tool
    Polypeptide UniProtKB:F1QY24 (1) 391 aa
    Sequence Information (all 12)
    ORTHOLOGY for agxta ( Chr: 6 )
    CITATIONS (19)