ZFIN ID: ZDB-GENE-040718-144
Gene Name: ras homolog family member Cb
Gene Symbol: rhocb    Nomenclature History

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Previous Names: rhoad, zgc:92350

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including actin cytoskeleton organization; skeletal muscle satellite cell migration; and wound healing, spreading of cells. Predicted to colocalize with the plasma membrane. Is expressed in dorsal aorta; intersegmental vessel; neural tube; and posterior cardinal vein. Orthologous to human RHOC (ras homolog family member C).
Genome Resources: Alliance (1),  Gene:436718 (1),  Ensembl(GRCz11):ENSDARG00000018328 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la016330Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27222 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rhocb N/A 2
    MO2-rhocb N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rhocb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH rhocb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process skeletal muscle satellite cell migration (more)
    Cellular Component membrane (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 23)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR005225 Small GTP-binding protein domain
    Family IPR001806 Small GTPase
    Family IPR003578 Small GTPase Rho
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rhocb-201 (1)    Ensembl 1027
    rhocb-202 (1)    Ensembl 516
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rhocb No data available
    MARKER RELATIONSHIPS
    rhocb Contained in: [BAC] CH211-254N4 (1), DKEYP-38G6 (1)
    rhocb Encodes: [cDNA] MGC:92350 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002445 (1) 1065 nt
    Genomic GenBank:AL954868 (1) 194224 nt
    Select Tool
    Polypeptide UniProtKB:Q6DHE8 (1) 193 aa
    Sequence Information (all 13)
    ORTHOLOGY for rhocb ( Chr: 8 )
    CITATIONS (30)