ZFIN ID: ZDB-GENE-040718-134
Gene Name: guanine nucleotide binding protein (G protein), beta polypeptide 3a
Gene Symbol: gnb3a    Nomenclature History

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Previous Names: gnb3l, zgc:92641

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have G-protein gamma-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to localize to cytoplasm and heterotrimeric G-protein complex. Is expressed in nervous system. Human ortholog(s) of this gene implicated in artery disease (multiple); congenital stationary night blindness 1H; familial hyperlipidemia; mental depression; and type 2 diabetes mellitus. Orthologous to human GNB3 (G protein subunit beta 3).
Genome Resources: Alliance (1),  Gene:436710 (1),  Ensembl(GRCz11):ENSDARG00000004358 (1)
GENE EXPRESSION
All Expression Data: 16 figures from 6 publications
Directly Submitted Expression Data: 7 figures (12 images) from Thisse et al., 2004 [MGC:92641]
Wild-type Stages, Structures: Segmentation:20-25 somites (19.0h-22.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010469Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9308 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12105 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gnb3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital stationary night blindness 1H Alliance Night blindness, congenital stationary, type 1H 617024
    essential hypertension Alliance {Hypertension, essential, susceptibility to} 145500
    DISEASE ASSOCIATED WITH gnb3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process signal transduction (more)
    Cellular Component cytoplasm (more)
    Molecular Function G-protein gamma-subunit binding (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gnb3a-201 (1)    Ensembl 1958
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gnb3a No data available
    MARKER RELATIONSHIPS
    gnb3a Contained in: [BAC] CH73-66F2 (1), CH211-69G19 (1), DKEY-197A20 (1) (order this)
    gnb3a Encodes: [cDNA] MGC:92641 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002437 (1) 1964 nt
    Genomic GenBank:CT027619 (1) 182366 nt
    Select Tool
    Polypeptide UniProtKB:Q6DH55 (1) 340 aa
    Sequence Information (all 14)
    ORTHOLOGY for gnb3a ( Chr: 16 )
    CITATIONS (32)