Gene

nr4a2b

ID
ZDB-GENE-040718-103
Name
nuclear receptor subfamily 4, group A, member 2b
Symbol
nr4a2b Nomenclature History
Previous Names
  • nr4a2
  • ngf1b
  • NURR1 (1)
  • zgc:92696
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and glucocorticoid receptor binding activity. Involved in dopaminergic neuron differentiation; forebrain neuron development; and neutrophil homeostasis. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in Parkinson's disease. Is expressed in basal plate midbrain region; blood; cranial neural crest; nervous system; and neuroblasts. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
30 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nr4a2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Intellectual developmental disorder with language impairment and early-onset DOPA-responsive dystonia-parkinsonism 619911
Associated With nr4a2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR003070 Orphan nuclear receptor
Family IPR003073 Orphan nuclear receptor, NURR type
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Orphan nuclear receptor Orphan nuclear receptor, NURR type Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:Q6DH08 586
UniProtKB:I6LBI6 584
UniProtKB:O42543 42
UniProtKB:F1QK43 586
UniProtKB:A0A2R8RWF0 584
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations