Gene

nr4a2b

ID
ZDB-GENE-040718-103
Name
nuclear receptor subfamily 4, group A, member 2b
Symbol
nr4a2b Nomenclature History
Previous Names
  • nr4a2
  • ngf1b
  • NURR1 (1)
  • zgc:92696
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and glucocorticoid receptor binding activity. Involved in dopaminergic neuron differentiation; forebrain neuron development; and neutrophil homeostasis. Predicted to localize to nucleus and transcription regulator complex. Is expressed in basal plate midbrain region; blood; cranial neural crest; nervous system; and neuroblasts. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human NR4A2 (nuclear receptor subfamily 4 group A member 2).
Genome Resources
Note
None
Expression
All Expression Data
27 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nr4a2b Human Ortholog
No data available
Associated With nr4a2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
Domain IPR001628 Zinc finger, nuclear hormone receptor-type
Family IPR001723 Nuclear hormone receptor
Family IPR003070 Orphan nuclear receptor
Family IPR003073 Orphan nuclear receptor, NURR type
Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
Domain Details Per Protein
Protein Length Nuclear hormone receptor Nuclear hormone receptor, ligand-binding domain Nuclear hormone receptor-like domain superfamily Orphan nuclear receptor Orphan nuclear receptor, NURR type Zinc finger, NHR/GATA-type Zinc finger, nuclear hormone receptor-type
UniProtKB:I6LBI6 584
UniProtKB:A0A2R8RWF0 584
UniProtKB:F1QK43 586
UniProtKB:Q6DH08 586
UniProtKB:O42543 42
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations