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ZIRC
ZFIN ID: ZDB-GENE-040713-2
Gene Name: hypermethylated in cancer 1
Gene Symbol: hic1    Nomenclature History

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Previous Names: etID142640.25 (1), zfHIC1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Exhibits DNA binding activity. Predicted to be involved in cellular response to DNA damage stimulus. Predicted to localize to the nucleus. Orthologous to human HIC1 (HIC ZBTB transcriptional repressor 1).
Genome Resources: Alliance (1),  Gene:436585 (1),  Ensembl(GRCz11):ENSDARG00000055493 (2)
GENE EXPRESSION
All Expression Data: text only from Bertrand et al., 2004
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10158 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19118 Point Mutation Unknown Premature Stop ENU
    sa45540 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hic1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hic1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intrinsic apoptotic signaling pathway in response to DNA damage (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 8)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hic1-201 (1)    Ensembl 2517
    hic1-202 (1)    Ensembl 632
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hic1 No data available
    MARKER RELATIONSHIPS
    hic1 Contained in: [BAC] CH211-212M6 (1) (order this)
    hic1 Encodes: [cDNA] MGC:193845 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002314 (1) 2530 bp
    Genomic GenBank:CT027805 (1) 197979 bp
    Select Tool
    Polypeptide UniProtKB:Q70ZY9 (1) 737 aa
    Sequence Clusters UniGene:83225 (1)
    Sequence Information (all 15)
    ORTHOLOGY for hic1 ( Chr: 15 )
    CITATIONS (20)