ZFIN ID: ZDB-GENE-040712-6
Gene Name: CCM2 scaffold protein
Gene Symbol: ccm2
Sequence Ontology ID : SO:0000704

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Previous Names: MGC4607-like (1), si:dkeyp-86f6.1, TUF2 (1), valentine (1), vtn, zgc:110233

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:110233]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  brain, common cardinal vein, heart, intermediate cell mass of mesoderm (all 9) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi296aTg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028219Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m201 Point Mutation Exon 4 Premature Stop ENU
    s259 Unknown Unknown Unknown ENU
    sa37000 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-ccm2 (1), MO2-ccm2 (1), MO3-ccm2 (1), MO4-ccm2 (1)
    PHENOTYPE
    Data: 25 figures from 15 publications
    Observed in: anatomical system, aortic arch, atrioventricular canal endocardium Notch signaling involved in heart development, atrioventricular canal endocardium (all 34) expand
    DISEASE ASSOCIATED WITH ccm2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    cerebral cavernous malformation 2 Cerebral cavernous malformations-2 603284
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior axis specification (more)
    Cellular Component cytoplasm (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006020 (1)
  • InterPro:IPR026159 (1)
  • InterPro:IPR032375 (1)
  • PROSITE:PS01179 (1)
  • Pfam:PF16545 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ccm2-001 (1) 1886
    ncRNA ccm2-002 (1) 720
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ccm2
    tg(hsp70l:ccm2-ires-egfp)
    MARKER RELATIONSHIPS
    ccm2Contained in: [BAC] CH211-261F7 (1) (order this), DKEYP-86F6 (1)
    ccm2Encodes: [cDNA] MGC:110233 (1) (order this), MGC:191358 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002315 (1) 1535bp
    Genomic GenBank:BX511009 (1) 122167bp
    Select Tool
    Polypeptide UniProtKB:Q6DRP4 (1) 455aa
    Sequence Clusters UniGene:107920 (1)
    Sequence Information (all 21)
    OTHER ccm2 GENE PAGES
  • Alliance (1)
  • Gene:436586 (1)
  • VEGA:OTTDARG00000009060 (1)
  • Ensembl(GRCz10):ENSDARG00000013705 (1)
  • ORTHOLOGY for ccm2 (Chr: 20)
    CITATIONS (46)