ZFIN ID: ZDB-GENE-040712-6
Gene Name: cerebral cavernous malformation 2
Gene Symbol: ccm2

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Previous Names: MGC4607-like (1), si:dkeyp-86f6.1, TUF2 (1), valentine (1), vtn, zgc:110233

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(Including Attributions)
Location: Chr: 20 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:110233]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  brain, common cardinal vein, heart, intermediate cell mass of mesoderm (all 9) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi296aTg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028219Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m201 Point Mutation Exon 4 Premature Stop ENU
    s259 Unknown Unknown Unknown ENU
    sa37000 Point Mutation Unknown Splice Site ENU
    Targeting reagents: MO1-ccm2 (1), MO2-ccm2 (1), MO3-ccm2 (1), MO4-ccm2 (1)
    PHENOTYPE
    Data: 24 figures from 14 publications
    Observed in: anatomical system, aortic arch, atrium, blood (all 29) expand
    DISEASE ASSOCIATED WITH ccm2 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    cerebral cavernous malformation 2 Cerebral cavernous malformations-2 603284
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anterior/posterior axis specification (more)
    Cellular Component cytoplasm (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006020 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR026159 (1)
  • InterPro:IPR032375 (1)
  • PROSITE:PS01179 (1)
  • Pfam:PF16545 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ccm2-001 (1) 1886
    ncRNA ccm2-002 (1) 720
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ccm2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ccm2Contained in: [BAC] CH211-261F7 (1) (order this), DKEYP-86F6 (1)
    ccm2Encodes: [cDNA] MGC:110233 (1) (order this), MGC:191358 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002315 (1) 2281bp
    Genomic GenBank:BX511009 (1) 122167bp
    Select Tool
    Polypeptide UniProtKB:Q6DRP4 (1) 455aa
    Sequence Clusters UniGene:107920 (1)
    Sequence Information (all 22)
    OTHER ccm2 GENE PAGES
  • Gene:436586 (1)
  • VEGA:OTTDARG00000009060 (1)
  • Ensembl(GRCz10):ENSDARG00000013705 (1)
  • ORTHOLOGY for ccm2 (Chr: 20)
    Species Symbol Chromosome Accession # Evidence
    Human CCM2 7
  • Gene:83605
  • OMIM:607929
  • HGNC:21708
  • Amino acid sequence comparison (3)
    Mouse Ccm2 11
  • MGI:2384924
  • Gene:216527
  • Amino acid sequence comparison (2)
    Download Curated Orthology
    CITATIONS (40)