Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040712-6
Gene Name: cerebral cavernous malformation 2
Gene Symbol: ccm2
Previous Names: TUF2 (1), MGC4607-like (1), si:dkeyp-86f6.1, valentine, vtn, zgc:110233
Location: Chr: 20   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:110233]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  brain, common cardinal vein, heart, intermediate cell mass of mesoderm (all 9) expand
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 13 genotypes
Alleles: hi296aTg, la028219Tg, m201, s259
Knockdown reagents: MO1-ccm2 (1), MO2-ccm2 (1), MO3-ccm2 (1), MO4-ccm2 (1)
PHENOTYPE
Data: 20 figures from 13 publications
Observed in: anatomical system, aortic arch, atrium, blood (all 25) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Cerebral cavernous malformations-2 603284
GENE ONTOLOGY
Ontology GO Term
Biological Process cell-cell junction assembly (more)
Cellular Component cytoplasm (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR006020 (1)
  • InterPro:IPR011993 (1)
  • InterPro:IPR026159 (1)
  • PROSITE:PS01179 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ccm2-001 (1) 1886
    ncRNA ccm2-002 (1) 720
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM ccm2 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ccm2 Contained in: [BAC] CH211-261F7 (1) (order this), DKEYP-86F6 (1)
    ccm2 Encodes: [cDNA] MGC:110233 (1) (order this), MGC:191358 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002315 (1) 1535 bp
    Genomic GenBank:BX511009 (1) 122167 bp
    Select Tool
    Polypeptide UniProtKB:Q6DRP4 (1) 455 aa
    Sequence Clusters UniGene:107920 (1)
    Sequence Information (all 26)
    OTHER ccm2 GENE PAGES
  • Gene:436586 (1)
  • VEGA:OTTDARG00000009060 (1)
  • Ensembl(Zv9):ENSDARG00000013705 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA
    Zebrafish ccm2 20  
    Human CCM2 7 (7p13)
  • OMIM:607929
  • Gene:83605
  • Mouse Ccm2 11 ( 4.45 cM)
  • MGI:2384924
  • Gene:216527
  • Orthology Details
    CITATIONS (37)