Gene

htra1a

ID
ZDB-GENE-040704-64
Name
HtrA serine peptidase 1a
Symbol
htra1a Nomenclature History
Previous Names
  • htra1
  • zgc:92029
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have insulin-like growth factor binding activity and serine-type endopeptidase activity. Involved in regulation of fibroblast growth factor receptor signaling pathway. Predicted to localize to cytosol and extracellular region. Is expressed in mesoderm and somite. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Kim et al., 2012
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With htra1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
age related macular degeneration 7 Alliance {Macular degeneration, age-related, 7} 610149
age related macular degeneration 7 Alliance {Macular degeneration, age-related, neovascular type} 610149
CADASIL Alliance CARASIL syndrome 600142
CADASIL 2 Alliance Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 616779
Associated With htra1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000867 Insulin-like growth factor-binding protein, IGFBP
Domain IPR001478 PDZ domain
Domain IPR002350 Kazal domain
Family IPR001940 Peptidase S1C
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR036034 PDZ superfamily
Homologous_superfamily IPR036058 Kazal domain superfamily
Domain Details Per Protein
Protein Length Growth factor receptor cysteine-rich domain superfamily Insulin-like growth factor-binding protein, IGFBP Kazal domain Kazal domain superfamily PDZ domain PDZ superfamily Peptidase S1C Peptidase S1, PA clan
UniProtKB:B2GT42 479
UniProtKB:Q6GMI0 479
UniProtKB:A0A2R8QHQ0 479
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations