ZFIN ID: ZDB-GENE-040704-64
Gene Name: HtrA serine peptidase 1a
Gene Symbol: htra1a    Nomenclature History

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Previous Names: htra1, zgc:92029

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have insulin-like growth factor binding activity and serine-type endopeptidase activity. Involved in regulation of fibroblast growth factor receptor signaling pathway. Predicted to localize to cytosol and extracellular region. Is expressed in mesoderm and somite. Human ortholog(s) of this gene implicated in CADASIL (multiple); hypertension; and macular degeneration (multiple). Orthologous to human HTRA1 (HtrA serine peptidase 1).
Genome Resources: Alliance (1),  Gene:431766 (1),  Ensembl(GRCz11):ENSDARG00000032831 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:92029]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1585 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10864 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12950 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18228 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23058 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-htra1a N/A 1
    MO2-htra1a N/A 1
    DISEASE ASSOCIATED WITH htra1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    age related macular degeneration 7 Alliance {Macular degeneration, age-related, 7} 610149
    {Macular degeneration, age-related, neovascular type} 610149
    CADASIL Alliance CARASIL syndrome 600142
    CADASIL 2 Alliance Cerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukoencephalopathy, type 2 616779
    DISEASE ASSOCIATED WITH htra1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of fibroblast growth factor receptor signaling pathway (more)
    Cellular Component cytoplasm (more)
    Molecular Function growth factor binding (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA htra1a-201 (1)    Ensembl 2078
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM htra1a No data available
    MARKER RELATIONSHIPS
    htra1a Contained in: [BAC] CH211-208G24 (1), DKEY-237E17 (1) (order this)
    htra1a Encodes: [cDNA] MGC:92029 (1), MGC:192839 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002219 (1) 2055 nt
    Genomic GenBank:AL773596 (1) 206778 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A2R8QHQ0 (1) 479 aa
    Sequence Information (all 16)
    ORTHOLOGY for htra1a ( Chr: 17 )
    CITATIONS (24)