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General Information
ZIRC
ZFIN ID: ZDB-GENE-040704-60
Gene Name: growth arrest and DNA-damage-inducible, alpha, b
Gene Symbol: gadd45ab    Nomenclature History

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Previous Names: gadd45a, zgc:91795

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to be involved in activation of MAPKKK activity and regulation of cell cycle. Predicted to localize to the cytoplasm and nucleus. Is expressed in several structures, including axis; choroidal fissure; eye; pancreas primordium; and pronephric mesoderm. Orthologous to human GADD45A (growth arrest and DNA damage inducible alpha).
Genome Resources: Alliance (1),  Gene:431763 (1),  Ensembl(GRCz11):ENSDARG00000104571 (1)
GENE EXPRESSION
All Expression Data: 11 figures from 4 publications
Directly Submitted Expression Data: 6 figures (20 images) from Thisse et al., 2004 [MGC:91795]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa45249 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-gadd45ab N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gadd45ab HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH gadd45ab VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of cell cycle (more)
    Cellular Component nucleus (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR004038 (1)
  • InterPro:IPR024824 (1)
  • InterPro:IPR029064 (1)
  • Pfam:PF01248 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gadd45ab-201 (1)    Ensembl 1193
    gadd45ab-202 (1)    Ensembl 896
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gadd45ab No data available
    MARKER RELATIONSHIPS
    gadd45ab Contained in: [BAC] DKEY-44G17 (1) (order this)
    gadd45ab Encodes: [cDNA] MGC:91795 (1) (order this), MGC:92199 (1) (order this), MGC:173868 (1) (order this), MGC:192085 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002216 (1) 1217 bp
    Genomic GenBank:CR391961 (1) 142090 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IKZ9 (1) 163 aa
    Sequence Clusters UniGene:83410 (1)
    Sequence Information (all 22)
    ORTHOLOGY for gadd45ab ( Chr: 6 )
    CITATIONS (39)