Gene

mthfd2

ID
ZDB-GENE-040704-20
Name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Symbol
mthfd2 Nomenclature History
Previous Names
  • wu:fb38b11
  • wu:fe12e11
  • zgc:91891
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Predicted to localize to mitochondrion. Is expressed in anterior neural tube and optic cup. Orthologous to human MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mthfd2 Human Ortholog
No data available
Associated With mthfd2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR020867 Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
Domain IPR020630 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
Domain IPR020631 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
Family IPR000672 Tetrahydrofolate dehydrogenase/cyclohydrolase
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length NAD(P)-binding domain superfamily Tetrahydrofolate dehydrogenase/cyclohydrolase Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
UniProtKB:Q4F8H3 338
UniProtKB:Q6GMK2 338
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations