header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040704-20
Gene Name: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
Gene Symbol: mthfd2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: wu:fb38b11, wu:fe12e11, zgc:91891

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have methenyltetrahydrofolate cyclohydrolase activity; methylenetetrahydrofolate dehydrogenase (NAD+) activity; and methylenetetrahydrofolate dehydrogenase (NADP+) activity. Predicted to be involved in tetrahydrofolate interconversion. Is expressed in anterior neural tube and optic cup. Orthologous to human MTHFD2 (methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase).
Genome Resources: Alliance (1),  Gene:100004977 (1),  Ensembl(GRCz11):ENSDARG00000098646 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-mthfd2 N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH mthfd2 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH mthfd2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component mitochondrion (more)
Molecular Function catalytic activity (more)
GO Terms (all 8)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA mthfd2-201 (1)    Ensembl 2386
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM mthfd2 No data available
MARKER RELATIONSHIPS
mthfd2 Contained in: [BAC] CH211-275J6 (1) (order this)
mthfd2 Encodes: [EST] fb38b11, fe12e11
[cDNA] MGC:91891 (1) (order this), MGC:174756 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001002181 (1) 2350 bp
Genomic GenBank:CR847941 (1) 151835 bp
Select Tool
Polypeptide UniProtKB:Q4F8H3 (1) 338 aa
Sequence Clusters UniGene:76909 (1)
Sequence Information (all 19)
ORTHOLOGY for mthfd2 ( Chr: 5 )
CITATIONS (22)