ZFIN ID: ZDB-GENE-040629-3
Gene Name: RUNX family transcription factor 2a
Gene Symbol: runx2a    Nomenclature History

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Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in hemopoiesis and neuron differentiation. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in cleidocranial dysplasia. Is expressed in several structures, including cranium; fin; osteoblast; osteoprogenitor cell; and scale. Orthologous to human RUNX2 (RUNX family transcription factor 2).
Genome Resources: Alliance (1),  Gene:405784 (1),  Ensembl(GRCz11):ENSDARG00000040261 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2928 Point Mutation Unknown Splice Site ENU
sa13625 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-runx2a N/A 3
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH runx2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cleidocranial dysplasia Alliance Cleidocranial dysplasia 119600
    Cleidocranial dysplasia, forme fruste, dental anomalies only 119600
    Cleidocranial dysplasia, forme fruste, with brachydactyly 119600
    metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome Alliance Metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly 156510
    DISEASE ASSOCIATED WITH runx2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function DNA-binding transcription factor activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000040 Acute myeloid leukemia 1 protein (AML1)/Runt
    Homologous_superfamily IPR008967 p53-like transcription factor, DNA-binding
    Homologous_superfamily IPR012346 p53/RUNT-type transcription factor, DNA-binding domain superfamily
    Domain IPR013524 Runt domain
    Domain IPR013711 Runx, C-terminal domain
    Family IPR016554 Runt-related transcription factor RUNX
    Homologous_superfamily IPR027384 Runx, central domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA runx2a-201 (1)    Ensembl 1650
    runx2a-202 (1)    Ensembl 1498
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM runx2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(runx2a:GAL4-VP16-2A-mCherry) runx2a 2AGAL4mCherryVP16 Danio rerio 1 1
    MARKER RELATIONSHIPS
    runx2a Contained in: [BAC] CH211-34C18 (1), CH211-42B22 (1), CH211-253F14 (1)
    runx2a Encodes: [EST] eu739 (1)
    [cDNA] MGC:195229 (1), MGC:195237 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212858 (1) 1650 bp
    Genomic GenBank:BX510331 (1) 150762 bp
    Select Tool
    Polypeptide UniProtKB:B3DKD9 (1) 467 aa
    Sequence Information (all 41)
    ORTHOLOGY for runx2a ( Chr: 17 )
    CITATIONS (81)