ZFIN ID: ZDB-GENE-040625-95
Gene Name: nudix (nucleoside diphosphate linked moiety X)-type motif 15
Gene Symbol: nudt15    Nomenclature History

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Previous Name: zgc:86852

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity. Predicted to be involved in dGTP catabolic process. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in thiopurine S-methyltransferase deficiency. Orthologous to human NUDT15 (nudix hydrolase 15).
Genome Resources: Alliance (1),  Gene:415197 (1),  Ensembl(GRCz11):ENSDARG00000113961 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6902873]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa26685 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nudt15 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Thiopurines, poor metabolism of, 2} 616903
    DISEASE ASSOCIATED WITH nudt15 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dGTP catabolic process (more)
    Cellular Component cytosol (more)
    Molecular Function hydrolase activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nudt15 No data available
    MARKER RELATIONSHIPS
    nudt15 Encodes: [EST] IMAGE:6902873 (1)
    [cDNA] MGC:86852 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002107 (1)
    Genomic GenBank:CU928189 (1) 38125 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8RL21 (1) 172 aa
    Sequence Information (all 18)
    ORTHOLOGY for nudt15 ( Chr: 6 )
    CITATIONS (17)