ZFIN ID: ZDB-GENE-040625-7
Gene Name: aldo-keto reductase family 1, member B1 (aldose reductase), tandem duplicate 1
Gene Symbol: akr1b1.1    Nomenclature History

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Previous Names: akr1b1, zgc:86611 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have alditol:NADP+ 1-oxidoreductase activity. Predicted to be involved in oxidation-reduction process. Predicted to localize to the cytosol. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B).
Genome Resources: Alliance (1),  Gene:415138 (1),  Ensembl(GRCz11):ENSDARG00000006215 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu329]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa16601 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH akr1b1.1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH akr1b1.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process oxidation-reduction process (more)
    Cellular Component cytosol (more)
    Molecular Function oxidoreductase activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018170 Aldo/keto reductase, conserved site
    Family IPR020471 Aldo/keto reductase
    Domain IPR023210 NADP-dependent oxidoreductase domain
    Homologous_superfamily IPR036812 NADP-dependent oxidoreductase domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA akr1b1-201 (1)    Ensembl 1293
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM akr1b1.1 No data available
    MARKER RELATIONSHIPS
    akr1b1.1 Contained in: [BAC] DKEY-14K9 (1) (order this), DKEY-180P18 (1) (order this)
    akr1b1.1 Encodes: [EST] eu329 (1)
    [cDNA] MGC:86611 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001002048 (1) 1187 bp
    Genomic GenBank:BX571796 (1) 130699 bp
    Select Tool
    Polypeptide UniProtKB:Q5TYY5 (1) 315 aa
    Sequence Information (all 14)
    ORTHOLOGY for akr1b1.1 ( Chr: 4 )
    CITATIONS (21)