ZFIN ID: ZDB-GENE-040625-21
Gene Name: SUMO1 activating enzyme subunit 1
Gene Symbol: sae1    Nomenclature History

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Previous Names: fa28b04, sae2a (1), uble1a (1), wu:fa28b04 (1), zgc:86633

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have SUMO activating enzyme activity and protein C-terminus binding activity. Involved in definitive hemopoiesis; hematopoietic stem cell homeostasis; and protein sumoylation. Predicted to localize to SUMO activating enzyme complex and cytoplasm. Is expressed in brain. Orthologous to human SAE1 (SUMO1 activating enzyme subunit 1).
Genome Resources: Alliance (1),  Gene:415148 (1),  Ensembl(GRCz11):ENSDARG00000010487 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6910490]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Day 4 (96.0h-120.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hkz5 Point Mutation Exon 7 Premature Stop ENU
la019246Tg Transgenic Insertion Unknown Unknown DNA
la019247Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22643 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • DISEASE ASSOCIATED WITH sae1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sae1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process definitive hemopoiesis (more)
    Cellular Component SUMO activating enzyme complex (more)
    Molecular Function protein C-terminus binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sae1-201 (1)    Ensembl 1474
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sae1 No data available
    MARKER RELATIONSHIPS
    sae1 Contained in: [BAC] DKEY-31M14 (1) (order this)
    sae1 Encodes: [EST] fa28b04, IMAGE:6910490 (1)
    [cDNA] MGC:86633 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002058 (1) 1495 nt
    Genomic GenBank:CR855332 (1) 212455 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q6IQS6 (1) 348 aa
    Sequence Information (all 13)
    ORTHOLOGY for sae1 ( Chr: 15 )
    CITATIONS (34)