Gene

sms

ID

ZDB-GENE-040625-150

Name

spermine synthase

Symbol

sms Nomenclature History

Previous Names

zgc:86583

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have spermine synthase activity. Involved in spermine biosynthetic process. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Snyder type. Orthologous to human SMS (spermine synthase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Keightley et al., 2013

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Frohnhöfer et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With sms Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
syndromic X-linked intellectual disability Snyder type	Alliance	Intellectual developmental disorder, X-linked syndromic, Snyder-Robinson type	309583

Associated With sms Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR030373	Polyamine biosynthesis domain, conserved site
Domain	IPR030374	Polyamine biosynthesis domain
Domain	IPR035246	Spermidine synthase, tetramerisation domain
Domain	IPR040900	Spermine synthase, N-terminal
Family	IPR015576	Spermine synthase, animal
Homologous_superfamily	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily
Homologous_superfamily	IPR037163	Spermidine synthase, tetramerisation domain superfamily