ZFIN ID: ZDB-GENE-040625-141
Gene Name: DNA-damage regulated autophagy modulator 2b
Gene Symbol: dram2b    Nomenclature History

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Previous Names: dram2, fj35e01, wu:fj35e01, zgc:86754

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to be involved in regulation of autophagy. Predicted to localize to lysosome. Human ortholog(s) of this gene implicated in cone-rod dystrophy. Orthologous to human DRAM2 (DNA damage regulated autophagy modulator 2).
Genome Resources: Alliance (1),  Gene:415225 (1),  Ensembl(GRCz11):ENSDARG00000044241 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6892548]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24049 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37394 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa43737 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH dram2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cone-rod dystrophy 21 616502
    DISEASE ASSOCIATED WITH dram2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of autophagy (more)
    Cellular Component integral component of membrane (more)
    Molecular Function molecular_function (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dram2b-201 (1)    Ensembl 1954
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dram2b No data available
    MARKER RELATIONSHIPS
    dram2b Contained in: [Fosmid] ZFOS-465A5 (1)
    dram2b Encodes: [EST] fj35e01, IMAGE:6892548 (1)
    [cDNA] MGC:86754 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002135 (1)
    Genomic GenBank:CU855600 (1) 39422 nt
    Select Tool
    Polypeptide UniProtKB:F1R7U0 (1) 273 aa
    Sequence Information (all 14)
    ORTHOLOGY for dram2b ( Chr: 22 )
    CITATIONS (27)