ZFIN ID: ZDB-GENE-040625-14
Gene Name: deoxyguanosine kinase
Gene Symbol: dguok    Nomenclature History

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Previous Name: zgc:86625

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have deoxyguanosine kinase activity. Predicted to be involved in nucleobase-containing compound metabolic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; and mitochondrial metabolism disease. Orthologous to human DGUOK (deoxyguanosine kinase).
Genome Resources: Alliance (1),  Gene:100005067 (1),  Ensembl(GRCz11):ENSDARG00000075395 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6892866]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-dguok
1
CRISPR2-dguok
1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH dguok HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4 Alliance Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4 617070
mitochondrial DNA depletion syndrome 3 Alliance Mitochondrial DNA depletion syndrome 3 (hepatocerebral type) 251880
Portal hypertension, noncirrhotic 617068
DISEASE ASSOCIATED WITH dguok VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process nucleobase-containing compound metabolic process (more)
Cellular Component cytoplasm (more)
Molecular Function ATP binding (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA dguok-201 (1)    Ensembl 1182
dguok-202 (1)    Ensembl 851
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM dguok No data available
MARKER RELATIONSHIPS
dguok Contained in: [BAC] CH211-112B19, CH211-275J6 (1), DKEY-204G14 (order this)
dguok Encodes: [EST] IMAGE:6892866 (1)
[cDNA] MGC:86625 (1), MGC:173877 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001100091 (1) 1182 nt
Genomic GenBank:CR925780 166407 nt
Select Tool
Polypeptide UniProtKB:A5WUY2 (1) 269 aa
Sequence Information (all 20)
ORTHOLOGY for dguok ( Chr: 5 )
CITATIONS (20)