Gene

dguok

ID
ZDB-GENE-040625-14
Name
deoxyguanosine kinase
Symbol
dguok Nomenclature History
Previous Names
  • zgc:86625
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to enable deoxyguanosine kinase activity. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; mitochondrial metabolism disease; and portal hypertension. Orthologous to human DGUOK (deoxyguanosine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dguok Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4 Alliance Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal recessive 4 617070
mitochondrial DNA depletion syndrome 3 Alliance Mitochondrial DNA depletion syndrome 3 (hepatocerebral type) 251880
Portal hypertension, noncirrhotic, 1 617068
Associated With dguok Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR031314 Deoxynucleoside kinase domain
Family IPR002624 Deoxynucleoside kinase
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length Deoxynucleoside kinase Deoxynucleoside kinase domain P-loop containing nucleoside triphosphate hydrolase
UniProtKB:A5WUY2 269
UniProtKB:F8W639 181
UniProtKB:Q6IQT3 269
UniProtKB:A8E537 269
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations