ZFIN ID: ZDB-GENE-040625-109
Gene Name: ELL associated factor 1
Gene Symbol: eaf1    Nomenclature History

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Previous Names: wu:fb52f06, zgc:86818

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Exhibits armadillo repeat domain binding activity; beta-catenin binding activity; and chromatin binding activity. Involved in several processes, including animal organ development; cell migration involved in gastrulation; and convergent extension involved in axis elongation. Predicted to localize to super elongation complex. Is expressed in several structures, including blastoderm; blastodisc; nervous system; pleuroperitoneal region; and presumptive neural retina. Orthologous to human EAF1 (ELL associated factor 1).
Genome Resources: Alliance (1),  Gene:415205 (1),  Ensembl(GRCz11):ENSDARG00000070795 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hza1 Small Deletion Exon 1 Unknown CRISPR
sa13760 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-eaf1
    1
    CRISPR2-eaf1
    1
    CRISPR3-eaf1
    1
    CRISPR4-eaf1 1
    MO1-eaf1 N/A 6
    MO2-eaf1 N/A 2
    MO3-eaf1 N/A 4
    DISEASE ASSOCIATED WITH eaf1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH eaf1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription by RNA polymerase II (more)
    Cellular Component super elongation complex (more)
    Molecular Function armadillo repeat domain binding (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eaf1-201 (1)    Ensembl 1594
    eaf1-202 (1)    Ensembl 772
    ncRNA eaf1-003 (1)    Ensembl 820
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eaf1 No data available
    MARKER RELATIONSHIPS
    eaf1 Contained in: [BAC] CH211-198O19 (1)
    eaf1 Encodes: [EST] fb52f06, IMAGE:6907427 (1)
    [cDNA] MGC:86818 (1), MGC:174398 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001002115 (1) 1433 nt
    Genomic GenBank:AL845419 (1) 176379 nt
    Select Tool
    Polypeptide UniProtKB:Q6IQD2 (1) 253 aa
    Sequence Information (all 15)
    ORTHOLOGY for eaf1 ( Chr: 16 )
    CITATIONS (23)