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Gene

top1mt

ID
ZDB-GENE-040624-2
Name
DNA topoisomerase I mitochondrial
Symbol
top1mt Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to enable DNA binding activity and DNA topoisomerase type I (single strand cut, ATP-independent) activity. Predicted to act upstream of or within DNA topological change. Predicted to be located in chromosome and endoplasmic reticulum membrane. Orthologous to human TOP1MT (DNA topoisomerase I mitochondrial).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With top1mt Human Ortholog
No data available
Associated With top1mt Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR018521 DNA topoisomerase I, active site
Domain IPR000535 Major sperm protein (MSP) domain
Domain IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-type
Domain IPR013499 DNA topoisomerase I, eukaryotic-type
Domain IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-type
Domain IPR025834 Topoisomerase I C-terminal domain
Family IPR001631 DNA topoisomerase I
Family IPR016763 Vesicle-associated membrane-protein-associated protein
Homologous_superfamily IPR008962 PapD-like superfamily
Homologous_superfamily IPR011010 DNA breaking-rejoining enzyme, catalytic core
Homologous_superfamily IPR013030 DNA topoisomerase I, DNA binding, N-terminal domain 2
Homologous_superfamily IPR013034 DNA topoisomerase I, DNA binding, N-terminal domain 1
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type
Homologous_superfamily IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomain
Homologous_superfamily IPR036202 DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily
Domain Details Per Protein
Protein Length DNA breaking-rejoining enzyme, catalytic core DNA topoisomerase I DNA topoisomerase I, active site DNA topoisomerase I, catalytic core, alpha/beta subdomain DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type DNA topoisomerase I, catalytic core, eukaryotic-type DNA topoisomerase I, DNA binding, eukaryotic-type DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily DNA topoisomerase I, DNA binding, N-terminal domain 1 DNA topoisomerase I, DNA binding, N-terminal domain 2 DNA topoisomerase I, eukaryotic-type Immunoglobulin-like fold Major sperm protein (MSP) domain PapD-like superfamily Topoisomerase I C-terminal domain Vesicle-associated membrane-protein-associated protein
UniProtKB:Q6T721 600
UniProtKB:A0A0G2KFV1 549
UniProtKB:A0A0R4IUV0 150
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations