ZFIN ID: ZDB-GENE-040624-12
Gene Name: transient receptor potential cation channel, subfamily V, member 6
Gene Symbol: trpv6    Nomenclature History

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Previous Names: ecac (1), matt-und-schlapp (1), mus (1), zECaC (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Exhibits calcium channel activity. Involved in several processes, including calcium ion import; hypotonic salinity response; and response to calcium ion. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in hyperparathyroidism. Is expressed in several structures, including ball; digestive system; gill; integument; and pleuroperitoneal region. Orthologous to several human genes including TRPV6 (transient receptor potential cation channel subfamily V member 6).
Genome Resources: Alliance (1),  Gene:100000322 (1),  Ensembl(GRCz11):ENSDARG00000014496 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mi604 Small Deletion Unknown Unknown CRISPR
mi605 Indel Unknown Unknown CRISPR
mi606 Indel Unknown Unknown CRISPR
sa1510 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16780 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17082 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25007 Point Mutation Unknown Premature Stop ENU
    sa42673 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42674 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • t25927 Point Mutation Exon 9 Premature Stop
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-trpv6 1
    MO1-trpv6 N/A 3
    DISEASE ASSOCIATED WITH trpv6 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Hyperparathyroidism, transient neonatal 618188
    DISEASE ASSOCIATED WITH trpv6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process hypotonic salinity response (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium channel activity (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR005821 Ion transport domain
    Domain IPR020683 Ankyrin repeat-containing domain
    Family IPR008344 Transient receptor potential cation channel subfamily V member 5/6
    Family IPR024862 Transient receptor potential cation channel subfamily V
    Homologous_superfamily IPR036770 Ankyrin repeat-containing domain superfamily
    Repeat IPR002110 Ankyrin repeat
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA trpv6-201 (1)    Ensembl 2557
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM trpv6 No data available
    MARKER RELATIONSHIPS
    trpv6 Contained in: [BAC] DKEY-26C10 (1) (order this)
    trpv6 Encodes: [cDNA] MGC:162545 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001001849 (1) 2548 nt
    Genomic GenBank:CR388102 (1) 194602 nt
    Select Tool
    Polypeptide UniProtKB:A4QP05 (1) 709 aa
    Sequence Information (all 29)
    ORTHOLOGY for trpv6 ( Chr: 16 )
    CITATIONS (58)