ZFIN ID: ZDB-GENE-040623-1
Gene Name: parathyroid hormone 1a
Gene Symbol: pth1a    Nomenclature History

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Previous Name: pth1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Exhibits hormone activity. Involved in calcium ion homeostasis and epidermal cell differentiation. Predicted to localize to extracellular region. Is expressed in several structures, including gill; heart; integument; nervous system; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including chronic kidney disease; diabetes mellitus (multiple); familial isolated hypoparathyroidism; hyperphosphatemia; and secondary hyperparathyroidism. Orthologous to human PTH (parathyroid hormone).
Genome Resources: Alliance (1),  Gene:405886 (1),  Ensembl(GRCz11):ENSDARG00000093738 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-pth1a N/A 1
MO2-pth1a N/A 1
DISEASE ASSOCIATED WITH pth1a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
familial isolated hypoparathyroidism Alliance Hypoparathyroidism, familial isolated 1 146200
hypoparathyroidism Alliance Hypoparathyroidism, familial isolated 1 146200
DISEASE ASSOCIATED WITH pth1a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process calcium ion homeostasis (more)
Cellular Component extracellular region (more)
Molecular Function hormone activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA pth1a-201 (1)    Ensembl 676
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM pth1a No data available
MARKER RELATIONSHIPS
pth1a Contained in: [BAC] CH211-176L24 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_212950 (1) 699 nt
Genomic GenBank:CT033838 (1) 71968 nt
Select Tool
Polypeptide UniProtKB:F1QMK0 (1) 102 aa
Sequence Information (all 13)
ORTHOLOGY for pth1a ( Chr: 25 )
CITATIONS (36)