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General Information
ZIRC
ZFIN ID: ZDB-GENE-040622-3
Gene Name: neurofibromin 2b (merlin)
Gene Symbol: nf2b    Nomenclature History

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Previous Names: nf2 (1), NF2a

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have actin binding activity. Predicted to localize to the cytoskeleton. Used to study choledochal cyst. Human ortholog(s) of this gene implicated in familial meningioma; neurilemmomatosis; and neurofibromatosis 2. Orthologous to human NF2 (neurofibromin 2).
Genome Resources: Alliance (1),  Gene:405887 (1),  Ensembl(GRCz11):ENSDARG00000025567 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7147099]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi3332Tg Transgenic Insertion Intron 1 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13486 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23946 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45738 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nf2b N/A 2
    DISEASE ASSOCIATED WITH nf2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    neurilemmomatosis Alliance Schwannomatosis, somatic 162091
    neurofibromatosis 2 Alliance Neurofibromatosis, type 2 101000
    Meningioma, NF2-related, somatic 607174
    DISEASE ASSOCIATED WITH nf2b VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    choledochal cyst nf2bhi3332Tg standard conditions Sadler et al., 2005
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component cytoskeleton (more)
    Molecular Function actin binding (more)
    GO Terms (all 3)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript nf2b-203 (1)    Ensembl 1630
    mRNA nf2b-201 (1)    Ensembl 2154
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nf2b No data available
    MARKER RELATIONSHIPS
    nf2b Contained in: [BAC] DKEY-54M16 (1) (order this)
    nf2b Encodes: [EST] IMAGE:7147099 (1) (order this)
    [cDNA] MGC:123124 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_212951 (1) 2176 bp
    Genomic GenBank:CR847847 (1) 76887 bp
    Select Tool
    Polypeptide UniProtKB:Q32PS2 (1) 586 aa
    Sequence Clusters UniGene:38497 (1)
    Sequence Information (all 15)
    ORTHOLOGY for nf2b ( Chr: 21 )
    CITATIONS (28)