ZFIN ID: ZDB-GENE-040611-3
Gene Name: neuropilin 2b
Gene Symbol: nrp2b    Nomenclature History

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Previous Names: npn-2B (1), id:ibd2759, sb:cb513

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have metal ion binding activity; semaphorin receptor activity; and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including axon development; neural crest cell migration; and vasculogenesis. Predicted to localize to the integral component of membrane. Is expressed in several structures, including head; mesoderm; nervous system; neural crest cell; and neural plate. Orthologous to human NRP2 (neuropilin 2).
Genome Resources: Alliance (1),  Gene:405902 (1),  Ensembl(GRCz11):ENSDARG00000038446 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
mn0126Gt Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • pku418Et Transgenic Insertion Intron 3 Unknown DNA
    sa7177 Point Mutation Unknown Premature Stop ENU
    sa18942 Unknown Unknown Splice Site ENU
    sa34590 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34591 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41380 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nrp2b
    1
    CRISPR2-nrp2b
    1
    CRISPR3-nrp2b
    1
    MO1-nrp2b N/A 1
    MO2-nrp2b N/A 3
    MO3-nrp2b N/A 2
    DISEASE ASSOCIATED WITH nrp2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nrp2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neural crest cell migration (more)
    Cellular Component integral component of membrane (more)
    Molecular Function metal ion binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000421 Coagulation factor 5/8 C-terminal domain
    Domain IPR000859 CUB domain
    Domain IPR000998 MAM domain
    Domain IPR022579 Neuropilin, C-terminal
    Family IPR014648 Neuropilin
    Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
    Homologous_superfamily IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
    Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nrp2b-201 (1)    Ensembl 4784
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nrp2b No data available
    MARKER RELATIONSHIPS
    nrp2b Contained in: [BAC] DKEY-27L20 (1) (order this), DKEY-235E19 (1) (order this)
    nrp2b Encodes: [EST] cb513 (1), ibd2759
    [cDNA] MGC:195214 (1), MGC:195234 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_212966 (1) 4817 nt
    Genomic GenBank:BX510337 (1) 170615 nt
    Select Tool
    Polypeptide UniProtKB:Q6T491 (1) 921 aa
    Sequence Information (all 37)
    ORTHOLOGY for nrp2b ( Chr: 9 )
    CITATIONS (49)