Gene

cacna1db

ID

ZDB-GENE-040525-3

Name

calcium channel, voltage-dependent, L type, alpha 1D subunit, b

Symbol

cacna1db Nomenclature History

Previous Names

cav1.3b (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Description

Predicted to enable low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Predicted to be involved in calcium ion import; membrane depolarization during action potential; and positive regulation of calcium ion-dependent exocytosis. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in atrium and cardiac ventricle. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human CACNA1D (calcium voltage-gated channel subunit alpha1 D).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Liu et al., 2022
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With cacna1db Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Primary aldosteronism, seizures, and neurologic abnormalities	615474
		Sinoatrial node dysfunction and deafness	614896

Associated With cacna1db Via Experimental Models

Human Disease	Fish	Conditions	Citations
congenital heart disease	AB + MO1-cacna1db	standard conditions	Liu et al., 2022

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005821	Ion transport domain
Domain	IPR014873	Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
Domain	IPR031649	Voltage-dependent L-type calcium channel, IQ-associated domain
Domain	IPR031688	Voltage-gated calcium channel subunit alpha, C-terminal
Family	IPR002077	Voltage-dependent calcium channel, alpha-1 subunit
Family	IPR005446	Voltage-dependent calcium channel, L-type, alpha-1 subunit
Family	IPR050599	Voltage-dependent calcium channel alpha-1 subunit
Homologous_superfamily	IPR027359	Voltage-dependent channel domain superfamily