Gene

cacna1db

ID
ZDB-GENE-040525-3
Name
calcium channel, voltage-dependent, L type, alpha 1D subunit, b
Symbol
cacna1db Nomenclature History
Previous Names
  • cav1.3b (1)
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable metal ion binding activity and voltage-gated calcium channel activity. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in atrium and cardiac ventricle. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including CFAP74 (cilia and flagella associated protein 74).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cacna1db Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Primary aldosteronism, seizures, and neurologic abnormalities 615474
Sinoatrial node dysfunction and deafness 614896
Associated With cacna1db Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR005821 Ion transport domain
Domain IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
Domain IPR031649 Voltage-dependent L-type calcium channel, IQ-associated domain
Domain IPR031688 Voltage-gated calcium channel subunit alpha, C-terminal
Family IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
Family IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunit
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
Domain Details Per Protein
Protein Length Immunoglobulin-like fold Ion transport domain Voltage-dependent calcium channel, alpha-1 subunit Voltage-dependent calcium channel, alpha-1 subunit, IQ domain Voltage-dependent calcium channel, L-type, alpha-1 subunit Voltage-dependent channel domain superfamily Voltage-dependent L-type calcium channel, IQ-associated domain Voltage-gated calcium channel subunit alpha, C-terminal
UniProtKB:Q6QRQ1 2040
UniProtKB:A0A0H2UKS6 207
UniProtKB:A0A0H2UKL7 413
UniProtKB:E9QIG7 1568
UniProtKB:X1WEG7 88
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations