Gene
cacna1db
- ID
- ZDB-GENE-040525-3
- Name
- calcium channel, voltage-dependent, L type, alpha 1D subunit, b
- Symbol
- cacna1db Nomenclature History
- Previous Names
-
- cav1.3b (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity and voltage-gated calcium channel activity. Predicted to act upstream of or within calcium ion transmembrane transport and regulation of monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Is expressed in atrium and cardiac ventricle. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including CFAP74 (cilia and flagella associated protein 74).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR014873 | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain |
| Domain | IPR031649 | Voltage-dependent L-type calcium channel, IQ-associated domain |
| Domain | IPR031688 | Voltage-gated calcium channel subunit alpha, C-terminal |
| Family | IPR002077 | Voltage-dependent calcium channel, alpha-1 subunit |
| Family | IPR005446 | Voltage-dependent calcium channel, L-type, alpha-1 subunit |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin-like fold | Ion transport domain | Voltage-dependent calcium channel, alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain | Voltage-dependent calcium channel, L-type, alpha-1 subunit | Voltage-dependent channel domain superfamily | Voltage-dependent L-type calcium channel, IQ-associated domain | Voltage-gated calcium channel subunit alpha, C-terminal |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q6QRQ1
|
2040 | ||||||||
|
UniProtKB:A0A0H2UKS6
|
207 | ||||||||
|
UniProtKB:A0A0H2UKL7
|
413 | ||||||||
|
UniProtKB:E9QIG7
|
1568 | ||||||||
|
UniProtKB:X1WEG7
|
88 |
| Type | Name | Length (nt) | Analysis |
|---|---|---|---|
| mRNA |
cacna1db-205
(1)
|
802 nt |
Interactions and Pathways
No data available
Plasmids