ZFIN ID: ZDB-GENE-040516-14
Gene Name: rho/rac guanine nucleotide exchange factor (GEF) 18a
Gene Symbol: arhgef18a    Nomenclature History

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Previous Names: arhgef18, wu:fc21e04, wu:fj05f11, zgc:85686

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have Rho guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to localize to plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18).
Genome Resources: Alliance (1),  Gene:407987 (1),  Ensembl(GRCz11):ENSDARG00000011157 (2)
GENE EXPRESSION
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la023658Tg Transgenic Insertion Unknown Unknown DNA
sa1637 Point Mutation Unknown Premature Stop ENU
sa16319 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19819 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25861 Point Mutation Unknown Splice Site ENU
    sa38343 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39886 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH arhgef18a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Retinitis pigmentosa 78 617433
    DISEASE ASSOCIATED WITH arhgef18a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of Rho protein signal transduction (more)
    Cellular Component plasma membrane (more)
    Molecular Function guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arhgef18a-201 (1)    Ensembl 4184
    arhgef18a-202 (1)    Ensembl 389
    arhgef18a-203 (1)    Ensembl 554
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arhgef18a No data available
    MARKER RELATIONSHIPS
    arhgef18a Contained in: [BAC] DKEY-57K2 (1) (order this)
    arhgef18a Encodes: [EST] fc21e04 (1), fj05f11 (1)
    [cDNA] MGC:85686 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_214818 (1) 4242 nt
    Genomic GenBank:BX539340 (1) 234470 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1REH9 (1) 940 aa
    Sequence Information (all 21)
    ORTHOLOGY for arhgef18a ( Chr: 2 )
    CITATIONS (24)