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ZIRC
ZFIN ID: ZDB-GENE-040426-990
Gene Name: WD repeat domain 45
Gene Symbol: wdr45    Nomenclature History

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Previous Names: zgc:56345 (1), zgc:77017

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in several processes, including autophagy of mitochondrion; protein lipidation; and protein localization to phagophore assembly site. Predicted to localize to the cytosol; extrinsic component of membrane; and phagophore assembly site membrane. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Orthologous to human WDR45 (WD repeat domain 45).
Genome Resources: Alliance (1),  Gene:393200 (1),  Ensembl(GRCz11):ENSDARG00000090219 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56345]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa41735 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH wdr45 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    neurodegeneration with brain iron accumulation 5 Alliance Neurodegeneration with brain iron accumulation 5 300894
    DISEASE ASSOCIATED WITH wdr45 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process autophagosome assembly (more)
    Cellular Component phagophore assembly site (more)
    Molecular Function phosphatidylinositol phosphate binding (more)
    GO Terms (all 14)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM wdr45 No data available
    MARKER RELATIONSHIPS
    wdr45 Encodes: [cDNA] MGC:56345 (1) (order this), MGC:77017 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200231 (1)
    Genomic GenBank:CABZ01063561 (1) 11772 bp
    Polypeptide UniProtKB:A0A0R4I9F8 (1) 358 aa
    Sequence Clusters UniGene:79570 (1)
    Sequence Information (all 20)
    ORTHOLOGY for wdr45 ( Chr: 10 )
    CITATIONS (20)