Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-040426-958
Gene Name: 3-hydroxymethyl-3-methylglutaryl-CoA lyase
Gene Symbol: hmgcl
Previous Name: zgc:56248
Location: Chr: 17   Details
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7142917]
  1 figure (1 image) from Thisse et al., 2004 [MGC:56248]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
  unspecified
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Alleles: la020016Tg
PHENOTYPE
Phenotype of Human Orthologue OMIM Phenotype ID
HMG-CoA lyase deficiency 246450
GENE ONTOLOGY
Ontology GO Term
Molecular Function catalytic activity (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000138 (1)
  • InterPro:IPR000891 (1)
  • InterPro:IPR013785 (1)
  • PROSITE:PS01062 (1)
  • PROSITE:PS50991 (1)
  • Pfam:PF00682 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA hmgcl-001 (1) 2008
    ncRNA hmgcl-002 (1) 535
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM hmgcl No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    hmgcl Contained in: [BAC] CH211-195O20 (1) (order this)
    hmgcl Encodes: [EST] IMAGE:7142917 (1) (order this)
    [cDNA] MGC:56248 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201215 (1) 2022 bp
    Genomic GenBank:CR391986 (1) 131805 bp
    Select Tool
    Polypeptide UniProtKB:F1QTF0 (1) 340 aa
    Sequence Clusters UniGene:79394 (1)
    Sequence Information (all 10)
    OTHER hmgcl GENE PAGES
  • Gene:394190 (1)
  • VEGA:OTTDARG00000022763 (1)
  • Ensembl(Zv9):ENSDARG00000021220 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish hmgcl 17  
    Human HMGCL 1 (1p36.1-p35)
  • OMIM:613898
  • Gene:3155
  • Mouse Hmgcl 4 ( 68.14 cM)
  • MGI:96158
  • Gene:15356
  • Orthology Details
    CITATIONS (19)