ZFIN ID: ZDB-GENE-040426-958
Gene Name: 3-hydroxy-3-methylglutaryl-CoA lyase
Gene Symbol: hmgcl    Nomenclature History

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Previous Name: zgc:56248

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process; leucine catabolic process; and lipid metabolic process. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase).
Genome Resources: Alliance (1),  Gene:394190 (1),  Ensembl(GRCz11):ENSDARG00000021220 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56248]
  1 figure (1 image) from Thisse et al., 2004 [IMAGE:7142917]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020016Tg Transgenic Insertion Unknown Unknown DNA
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hmgcl HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
HMG-CoA lyase deficiency 246450
DISEASE ASSOCIATED WITH hmgcl VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process ketone body biosynthetic process (more)
Molecular Function catalytic activity (more)
GO Terms (all 6)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA hmgcl-201 (1)    Ensembl 2008
ncRNA hmgcl-002 (1)    Ensembl 535
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hmgcl No data available
MARKER RELATIONSHIPS
hmgcl Contained in: [BAC] CH211-195O20 (1)
hmgcl Encodes: [EST] IMAGE:7142917 (1)
[cDNA] MGC:56248 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_201215 (1) 2022 nt
Genomic GenBank:CR391986 (1) 131805 nt
Select Tool
Polypeptide UniProtKB:F1QTF0 (1) 340 aa
Sequence Information (all 10)
ORTHOLOGY for hmgcl ( Chr: 17 )
CITATIONS (26)