ZFIN ID: ZDB-GENE-040426-958
Gene Name: 3-hydroxymethyl-3-methylglutaryl-CoA lyase
Gene Symbol: hmgcl

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Previous Name: zgc:56248

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(Including Attributions)
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7142917]
  1 figure (1 image) from Thisse et al., 2004 [MGC:56248]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
  unspecified
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020016Tg Transgenic Insertion Unknown Unknown DNA
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hmgcl HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
HMG-CoA lyase deficiency 246450
GENE ONTOLOGY
Ontology GO Term
Biological Process ketone body biosynthetic process (more)
Cellular Component mitochondrion (more)
Molecular Function catalytic activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000138 (1)
  • InterPro:IPR000891 (1)
  • InterPro:IPR013785 (1)
  • InterPro:IPR030020 (1)
  • PROSITE:PS01062 (1)
  • PROSITE:PS50991 (1)
  • Pfam:PF00682 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA hmgcl-001 (1) 2008
    ncRNA hmgcl-002 (1) 535
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM hmgcl No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    hmgclContained in: [BAC] CH211-195O20 (1) (order this)
    hmgclEncodes: [EST] IMAGE:7142917 (1) (order this)
    [cDNA] MGC:56248 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201215 (1) 2022bp
    Genomic GenBank:CR391986 (1) 131805bp
    Select Tool
    Polypeptide UniProtKB:F1QTF0 (1) 340aa
    Sequence Clusters UniGene:79394 (1)
    Sequence Information (all 10)
    OTHER hmgcl GENE PAGES
  • Gene:394190 (1)
  • VEGA:OTTDARG00000022763 (1)
  • Ensembl(GRCz10):ENSDARG00000021220 (1)
  • ORTHOLOGY for hmgcl (Chr: 17)
    Species Symbol Chromosome Accession # Evidence
    Human HMGCL 1
  • Gene:3155
  • OMIM:613898
  • HGNC:5005
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Hmgcl 4
  • MGI:96158
  • Gene:15356
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Download Curated Orthology
    CITATIONS (19)