ZFIN ID: ZDB-GENE-040426-958
Gene Name: 3-hydroxymethyl-3-methylglutaryl-CoA lyase
Gene Symbol: hmgcl
Previous Name: zgc:56248
Location: Chr: 17   Details
Nomenclature History
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7142917]
  1 figure (1 image) from Thisse et al., 2004 [MGC:56248]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
  unspecified
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS

Allele Type Mutagen Suppliers
la020016Tg Transgenic Insertion DNA
PHENOTYPE No data available
DISEASE ASSOCIATED WITH hmgcl HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
HMG-CoA lyase deficiency 246450
GENE ONTOLOGY
Ontology GO Term
Biological Process ketone body biosynthetic process (more)
Cellular Component mitochondrion (more)
Molecular Function catalytic activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000138 (1)
  • InterPro:IPR000891 (1)
  • InterPro:IPR013785 (1)
  • InterPro:IPR030020 (1)
  • PROSITE:PS01062 (1)
  • PROSITE:PS50991 (1)
  • Pfam:PF00682 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA hmgcl-001 (1) 2008
    ncRNA hmgcl-002 (1) 535
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hmgcl No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    hmgcl Contained in: [BAC] CH211-195O20 (1) (order this)
    hmgcl Encodes: [EST] IMAGE:7142917 (1) (order this)
    [cDNA] MGC:56248 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_201215 (1) 2022 bp
    Genomic GenBank:CR391986 (1) 131805 bp
    Select Tool
    Polypeptide UniProtKB:F1QTF0 (1) 340 aa
    Sequence Clusters UniGene:79394 (1)
    Sequence Information (all 10)
    OTHER hmgcl GENE PAGES
  • Gene:394190 (1)
  • VEGA:OTTDARG00000022763 (1)
  • Ensembl(Zv9):ENSDARG00000021220 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish hmgcl 17  
    Human HMGCL 1 (1p36.1-p35)
  • OMIM:613898
  • Gene:3155
  • Mouse Hmgcl 4 ( 68.14 cM)
  • MGI:96158
  • Gene:15356
  • Orthology Details
    CITATIONS (19)