ZFIN ID: ZDB-GENE-040426-955
Gene Name: cytochrome c oxidase assembly homolog 15 (yeast)
Gene Symbol: cox15    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: wu:fa18g06, zgc:56240, zgc:77422

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor. Predicted to be involved in heme A biosynthetic process. Predicted to localize to mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Leigh disease; fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 2; and hypertrophic cardiomyopathy. Orthologous to human COX15 (cytochrome c oxidase assembly homolog COX15).
Genome Resources: Alliance (1),  Gene:394181 (1),  Ensembl(GRCz11):ENSDARG00000075933 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56240]
  1 figure (1 image) from Thisse et al., 2004 [MGC:77422]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9235 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42108 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cox15 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    fatal infantile cardioencephalomyopathy due to cytochrome c oxidase deficiency 2 Alliance Cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 2 615119
    Leigh disease Alliance Leigh syndrome due to cytochrome c oxidase deficiency 256000
    DISEASE ASSOCIATED WITH cox15 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heme A biosynthetic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function oxidoreductase activity, acting on the CH-CH group of donors (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cox15 No data available
    MARKER RELATIONSHIPS
    cox15 Contained in: [BAC] CH211-250O1 (1)
    cox15 Encodes: [EST] fa18g06 (1)
    [cDNA] MGC:56240 (1), MGC:77422 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201206 (1) 1568 nt
    Genomic GenBank:CR354539 145294 nt
    Select Tool
    Polypeptide UniProtKB:F1R355 (1) 399 aa
    Sequence Information (all 19)
    ORTHOLOGY for cox15 ( Chr: 13 )
    CITATIONS (26)