ZFIN ID: ZDB-GENE-040426-948
Gene Name: YTH N(6)-methyladenosine RNA binding protein 2
Gene Symbol: ythdf2    Nomenclature History

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Previous Names: yth2, zgc:56224

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits N6-methyladenosine-containing RNA binding activity. Involved in several processes, including endothelial to hematopoietic transition; hematopoietic stem cell proliferation; and negative regulation of gene expression. Predicted to localize to cytoplasm. Orthologous to human YTHDF2 (YTH N6-methyladenosine RNA binding protein 2).
Genome Resources: Alliance (1),  Gene:393220 (1),  Ensembl(GRCz11):ENSDARG00000014498 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56224]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ch200 Small Deletion Unknown Premature Stop TALEN
sa1176 Point Mutation Unknown Premature Stop ENU
sa36430 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ythdf2 N/A 2
    TALEN1-ythdf2 1
    DISEASE ASSOCIATED WITH ythdf2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ythdf2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mRNA destabilization (more)
    Cellular Component cytoplasm (more)
    Molecular Function N6-methyladenosine-containing RNA binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ythdf2-201 (1)    Ensembl 3021
    ncRNA ythdf2-002 (1)    Ensembl 963
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ythdf2 No data available
    MARKER RELATIONSHIPS
    ythdf2 Contained in: [BAC] CH73-172J22 (1)
    [Fosmid] CH1073-358O18 (1)
    ythdf2 Encodes: [cDNA] MGC:56224 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200250 (1) 2131 nt
    Genomic GenBank:FP015965 (1) 73800 nt
    Select Tool
    Polypeptide UniProtKB:E7F1H9 (1) 613 aa
    Sequence Information (all 14)
    ORTHOLOGY for ythdf2 ( Chr: 17 )
    CITATIONS (26)