ZFIN ID: ZDB-GENE-040426-915
Gene Name: eukaryotic translation initiation factor 4A3
Gene Symbol: eif4a3    Nomenclature History

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Previous Names: ddx48, zgc:56139 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have RNA helicase activity and mRNA binding activity. Predicted to be involved in regulation of alternative mRNA splicing, via spliceosome. Predicted to localize to U2-type catalytic step 1 spliceosome; catalytic step 2 spliceosome; and nucleolus. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3).
Genome Resources: Alliance (1),  Gene:394053 (1),  Ensembl(GRCz11):ENSDARG00000102978 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56139]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa35168 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH eif4a3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Robin sequence with cleft mandible and limb anomalies 268305
    DISEASE ASSOCIATED WITH eif4a3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of alternative mRNA splicing, via spliceosome (more)
    Cellular Component nucleus (more)
    Molecular Function ATP binding (more)
    GO Terms (all 21)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA eif4a3-201 (1)    Ensembl 1493
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM eif4a3 No data available
    MARKER RELATIONSHIPS
    eif4a3 Contained in: [Fosmid] CH1073-160F22 (1)
    eif4a3 Encodes: [cDNA] MGC:56139 (1), MGC:192921 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201078 (1) 1528 nt
    Genomic GenBank:CU633990 (1) 33660 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IKW3 (1) 406 aa
    Sequence Information (all 16)
    ORTHOLOGY for eif4a3 ( Chr: 11 )
    CITATIONS (26)