ZFIN ID: ZDB-GENE-040426-901
Gene Name: platelet-derived growth factor receptor-like
Gene Symbol: pdgfrl    Nomenclature History

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Previous Names: zgc:56104, zgc:77677

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Exhibits identical protein binding activity. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Is expressed in cranium; head mesenchyme; notochord; sclerotome; and somite. Orthologous to human PDGFRL (platelet derived growth factor receptor like).
Genome Resources: Alliance (1),  Gene:393284 (1),  Ensembl(GRCz11):ENSDARG00000006456 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (6 images) from Thisse et al., 2004 [MGC:56104]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa79 Point Mutation Unknown Unknown ENU
sa6346 Point Mutation Unknown Premature Stop ENU
sa35708 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pdgfrl HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    colorectal cancer Alliance Colorectal cancer, somatic 114500
    hepatocellular carcinoma Alliance Hepatocellular cancer, somatic 114550
    DISEASE ASSOCIATED WITH pdgfrl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Molecular Function identical protein binding (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Family IPR042495 Platelet-derived growth factor receptor-like protein
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pdgfrl-201 (1)    Ensembl 1402
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pdgfrl No data available
    MARKER RELATIONSHIPS
    pdgfrl Contained in: [BAC] CH211-186K13 (1)
    pdgfrl Encodes: [cDNA] cssl:d212 (1), MGC:56104 (1), MGC:77677 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200314 (1) 1501 bp
    Genomic GenBank:CR384105 (1) 144285 bp
    Select Tool
    Polypeptide UniProtKB:F1QHI8 (1) 371 aa
    Sequence Information (all 17)
    ORTHOLOGY for pdgfrl ( Chr: 14 )
    CITATIONS (26)