Gene

eps8a

ID

ZDB-GENE-040426-871

Name

EGFR pathway substrate 8a, signaling adaptor

Symbol

eps8a Nomenclature History

Previous Names

eps8
zgc:56041 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to contribute to Rac guanyl-nucleotide exchange factor activity. Predicted to be involved in Rho protein signal transduction; positive regulation of ruffle assembly; and regulation of Rho protein signal transduction. Predicted to localize to ruffle membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Is expressed in nervous system; pronephric duct; and yolk syncytial layer. Orthologous to human EPS8 (epidermal growth factor receptor pathway substrate 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:56041 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eps8a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive nonsyndromic deafness 102	Alliance	?Deafness, autosomal recessive 102	615974

Associated With eps8a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR006020	PTB/PI domain
Domain	IPR013625	Tensin/EPS8 phosphotyrosine-binding domain
Domain	IPR033928	Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain
Domain	IPR035462	Eps8, SH3 domain
Domain	IPR041418	SAM domain
Family	IPR039801	Epidermal growth factor receptor kinase substrate 8-like
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily

Domain Details Per Protein

Protein	Length	Epidermal growth factor receptor kinase substrate 8-like	Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain	Eps8, SH3 domain	PH-like domain superfamily	PTB/PI domain	SAM domain	SH3 domain	SH3-like domain superfamily	Sterile alpha motif/pointed domain superfamily	Tensin/EPS8 phosphotyrosine-binding domain
UniProtKB:A0A0R4IIJ9 InterPro
UniProtKB:A0A8M3B1E2 InterPro	852
UniProtKB:Q7ZUV6 InterPro	804
UniProtKB:A0A8M3ARA8 InterPro	819
UniProtKB:A0A8M3AYF2 InterPro	872
UniProtKB:A0A8M3B8N1 InterPro	869
UniProtKB:A0A8M3AYF5 InterPro	851
UniProtKB:A0A8M3B1E6 InterPro	857
UniProtKB:A0A8M3ARA4 InterPro	864
UniProtKB:A0A8M6Z5A1 InterPro	871
UniProtKB:A0A8M3B8N5 InterPro	838
UniProtKB:A0A8M3AR15 InterPro	871
UniProtKB:A0A0R4IID9 InterPro	804
UniProtKB:A0A8M6YXX0 InterPro	838
UniProtKB:A0A8M3AR20 InterPro	839

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	eps8a-201 (1) Ensembl	Ensembl		3,170 nt	Select Tool ZFIN BLAST
mRNA	eps8a-202 (1) Ensembl	Ensembl		2,419 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations