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ZIRC
ZFIN ID: ZDB-GENE-040426-863
Gene Name: WD repeat domain 45B
Gene Symbol: wdr45b    Nomenclature History

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Previous Names: wdr45l, zgc:56002 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have phosphatidylinositol-3,5-bisphosphate binding activity and phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in several processes, including autophagy of mitochondrion; protein lipidation; and protein localization to phagophore assembly site. Predicted to localize to several cellular components, including the extrinsic component of membrane; lysosome; and phagophore assembly site membrane. Orthologous to human WDR45B (WD repeat domain 45B).
Genome Resources: Alliance (1),  Gene:393210 (1),  Ensembl(GRCz11):ENSDARG00000021557 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:56002]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa27847 Point Mutation Unknown Splice Site ENU
sa41925 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH wdr45b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodevelopmental disorder with spastic quadriplegia and brain abnormalities with or without seizures 617977
    DISEASE ASSOCIATED WITH wdr45b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process autophagosome assembly (more)
    Cellular Component lysosome (more)
    Molecular Function phosphatidylinositol-3,5-bisphosphate binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001680 (1)
  • InterPro:IPR015943 (1)
  • InterPro:IPR036322 (1)
  • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA wdr45b-201 (1)    Ensembl 1730
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM wdr45b No data available
    MARKER RELATIONSHIPS
    wdr45b Contained in: [Fosmid] CH1073-357B18 (1) (order this)
    wdr45b Encodes: [EST] fc33c03 (1)
    [cDNA] MGC:56002 (1) (order this), MGC:174552 (1) (order this), MGC:191326 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200240 (1)
    Genomic GenBank:CU611036 (1) 37797 bp
    Select Tool
    Polypeptide UniProtKB:A8KC31 (1) 344 aa
    Sequence Clusters UniGene:24228 (1)
    Sequence Information (all 24)
    ORTHOLOGY for wdr45b ( Chr: 12 )
    CITATIONS (19)