ZFIN ID: ZDB-GENE-040426-858
Gene Name: WW domain containing oxidoreductase
Gene Symbol: wwox    Nomenclature History

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Previous Name: zgc:55975 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have oxidoreductase activity. Involved in cellular calcium ion homeostasis. Predicted to localize to cytoplasm and nucleus. Is expressed in cranial nerve II; gut; heart; and presumptive cardiac ventricle heart tube. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; early infantile epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase).
Genome Resources: Alliance (1),  Gene:393887 (1),  Ensembl(GRCz11):ENSDARG00000007614 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55975]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014766Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la023354Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la023356Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9191 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32547 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38145 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44361 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-wwox N/A 1
    DISEASE ASSOCIATED WITH wwox HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive spinocerebellar ataxia 12 Alliance Spinocerebellar ataxia, autosomal recessive 12 614322
    early infantile epileptic encephalopathy 28 Alliance Epileptic encephalopathy, early infantile, 28 616211
    esophageal cancer Alliance Esophageal squamous cell carcinoma, somatic 133239
    DISEASE ASSOCIATED WITH wwox VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cellular calcium ion homeostasis (more)
    Cellular Component cytoplasm (more)
    Molecular Function oxidoreductase activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA wwox-202 (1)    Ensembl 1430
    ncRNA wwox-002 (1) 541
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM wwox No data available
    MARKER RELATIONSHIPS
    wwox Contained in: [BAC] CH211-176A19 (1)
    [Fosmid] CH1073-96K14 (1), CH1073-206O4 (1)
    wwox Encodes: [cDNA] MGC:55975 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200913 (1) 1914 nt
    Genomic GenBank:CR735110 (1) 119444 nt
    Select Tool
    Polypeptide UniProtKB:Q803A8 (1) 412 aa
    Sequence Information (all 23)
    ORTHOLOGY for wwox ( Chr: 25 )
    CITATIONS (28)