ZFIN ID: ZDB-GENE-040426-848
Gene Name: serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Gene Symbol: serpine2    Nomenclature History

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Previous Name: zgc:55929

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in Alzheimer's disease. Is expressed in midbrain hindbrain boundary; neural plate; olfactory system; otic vesicle; and pharyngeal arch 3-7 skeleton. Orthologous to human SERPINE2 (serpin family E member 2).
Genome Resources: Alliance (1),  Gene:393153 (1),  Ensembl(GRCz11):ENSDARG00000029353 (2)
GENE EXPRESSION
All Expression Data: 7 figures from 2 publications
Directly Submitted Expression Data: 6 figures (12 images) from Thisse et al., 2004 [MGC:55929]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019423Tg Transgenic Insertion Unknown Unknown DNA
sa993 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6397 Point Mutation Unknown Splice Site ENU
    sa42621 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH serpine2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH serpine2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of endopeptidase activity (more)
    Cellular Component extracellular space (more)
    Molecular Function serine-type endopeptidase inhibitor activity (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000215 Serpin family
    Conserved_site IPR023795 Serpin, conserved site
    Domain IPR023796 Serpin domain
    Homologous_superfamily IPR036186 Serpin superfamily
    Homologous_superfamily IPR042178 Serpin superfamily, domain 1
    Homologous_superfamily IPR042185 Serpin superfamily, domain 2
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA serpine2-201 (1)    Ensembl 1609
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM serpine2 No data available
    MARKER RELATIONSHIPS
    serpine2 Contained in: [Fosmid] CH1073-123J12 (1), CH1073-398D16 (1)
    serpine2 Encodes: [cDNA] MGC:55929 (1), MGC:191136 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200184 (1) 1586 bp
    Genomic GenBank:CU657924 (1) 41330 bp
    Select Tool
    Polypeptide UniProtKB:Q7ZVL5 (1) 395 aa
    Sequence Information (all 14)
    ORTHOLOGY for serpine2 ( Chr: 15 )
    CITATIONS (26)