ZFIN ID: ZDB-GENE-040426-822
Gene Name: cytochrome P450, family 2, subfamily K, polypeptide 22
Gene Symbol: cyp2k22    Nomenclature History

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Previous Names: zgc:55856, zgc:77813

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Involved in response to cortisol; response to progesterone; and response to testosterone. Predicted to localize to the cytoplasm and intracellular membrane-bounded organelle. Orthologous to human CYP2W1 (cytochrome P450 family 2 subfamily W member 1).
Genome Resources: Alliance (1),  Gene:393204 (1),  Ensembl(GRCz11):ENSDARG00000040433 (1)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55856]
Wild-type Stages, Structures: Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la024395Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19948 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cyp2k22 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH cyp2k22 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process response to cortisol (more)
    Cellular Component integral component of membrane (more)
    Molecular Function heme binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001128 Cytochrome P450
    Family IPR002401 Cytochrome P450, E-class, group I
    Conserved_site IPR017972 Cytochrome P450, conserved site
    Homologous_superfamily IPR036396 Cytochrome P450 superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cyp2k22-201 (1)    Ensembl 1773
    cyp2k22-203 (1)    Ensembl 746
    ncRNA cyp2k22-003 (1)    Ensembl 728
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cyp2k22 No data available
    MARKER RELATIONSHIPS
    cyp2k22 Contained in: [BAC] CH73-379F5 (1)
    cyp2k22 Encodes: [cDNA] MGC:55856 (1), MGC:77813 (1), MGC:174450 (1), MGC:191991 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_200235 (1) 1783 bp
    Genomic GenBank:CU855818 (1) 67068 bp
    Select Tool
    Polypeptide UniProtKB:F1QFW9 (1) 503 aa
    Sequence Information (all 25)
    ORTHOLOGY for cyp2k22 ( Chr: 3 )
    CITATIONS (35)