ZFIN ID: ZDB-GENE-040426-765
Gene Name: negative elongation factor complex member B
Gene Symbol: nelfb    Nomenclature History

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Previous Names: cobra1, fe01e12, wu:fe01e12 (1), zgc:55628

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Involved in positive regulation of hematopoietic stem cell differentiation. Predicted to localize to the NELF complex. Orthologous to human NELFB (negative elongation factor complex member B).
Genome Resources: Alliance (1),  Gene:393137 (1),  Ensembl(GRCz11):ENSDARG00000035505 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7144004]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12379 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17245 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20444 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nelfb N/A 1
    MO2-nelfb N/A 1
    DISEASE ASSOCIATED WITH nelfb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nelfb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of hematopoietic progenitor cell differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function molecular_function (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR010405 Cofactor of BRCA1
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nelfb-202 (1)    Ensembl 2269
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nelfb No data available
    MARKER RELATIONSHIPS
    nelfb Contained in: [BAC] RP71-1O1
    nelfb Encodes: [EST] fe01e12, IMAGE:7144004 (1)
    [cDNA] MGC:55628 (1), MGC:191838 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200168 (1) 2319 nt
    Genomic GenBank:AL831768 (1) 149457 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IWG6 (1) 609 aa
    Sequence Information (all 23)
    ORTHOLOGY for nelfb ( Chr: 5 )
    CITATIONS (24)