ZFIN ID: ZDB-GENE-040426-761
Gene Name: phosphatidylinositol binding clathrin assembly protein a
Gene Symbol: picalma    Nomenclature History

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Previous Names: picalm, zgc:55615

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have SNARE binding activity; clathrin heavy chain binding activity; and phosphatidylinositol binding activity. Predicted to be involved in clathrin-dependent endocytosis and synaptic vesicle budding from presynaptic endocytic zone membrane. Predicted to localize to clathrin-coated pit; cytoplasmic vesicle; and extrinsic component of presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human PICALM (phosphatidylinositol binding clathrin assembly protein).
Genome Resources: Alliance (1),  Gene:393901 (1),  Ensembl(GRCz11):ENSDARG00000012866 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55615]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la017499Tg Transgenic Insertion Unknown Unknown DNA
sa31786 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45411 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH picalma HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
    DISEASE ASSOCIATED WITH picalma VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process clathrin coat assembly (more)
    Cellular Component clathrin-coated vesicle (more)
    Molecular Function 1-phosphatidylinositol binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA picalma-201 (1)    Ensembl 3477
    picalma-202 (1)    Ensembl 2222
    picalma-204 (1)    Ensembl 825
    picalma-205 (1)    Ensembl 566
    Browsers: UCSCEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM picalma No data available
    MARKER RELATIONSHIPS
    picalma Contained in: [BAC] CH211-103F14 (1)
    picalma Encodes: [cDNA] MGC:55615 (1), MGC:174845 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200927 (1) 3270 nt
    Genomic GenBank:BX005332 (1) 189101 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QHW2 (1) 716 aa
    Sequence Information (all 74)
    ORTHOLOGY for picalma ( Chr: 10 )
    CITATIONS (22)