Gene

mkks

ID
ZDB-GENE-040426-757
Name
MKKS centrosomal shuttling protein
Symbol
mkks Nomenclature History
Previous Names
  • bbs6
  • zgc:55608
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to enable ATP binding activity and unfolded protein binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; establishment of pigment granule localization; and sensory organ development. Located in cytoplasm and nucleus. Used to study ciliopathy. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 6; McKusick-Kaufman syndrome; congenital heart disease; and obesity. Orthologous to human MKKS (MKKS centrosomal shuttling protein).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
16 figures from 9 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mkks Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bardet-Biedl syndrome 6 Alliance Bardet-Biedl syndrome 6 605231
McKusick-Kaufman syndrome Alliance McKusick-Kaufman syndrome 236700
Associated With mkks Via Experimental Models
Human Disease Fish Conditions Citations
ciliopathy WT + MO1-mkks control Tobin et al., 2008
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR002423 Chaperonin Cpn60/TCP-1 family
Family IPR028790 McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin
Homologous_superfamily IPR027409 GroEL-like apical domain superfamily
Homologous_superfamily IPR027410 TCP-1-like chaperonin intermediate domain superfamily
Homologous_superfamily IPR027413 GroEL-like equatorial domain superfamily
Domain Details Per Protein
Protein Length Chaperonin Cpn60/TCP-1 family GroEL-like apical domain superfamily GroEL-like equatorial domain superfamily McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin TCP-1-like chaperonin intermediate domain superfamily
UniProtKB:F1QCQ8 563
UniProtKB:Q7ZVV0 563
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations