ZFIN ID: ZDB-GENE-040426-752
Gene Name: NIMA-related kinase 2
Gene Symbol: nek2    Nomenclature History

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Previous Name: zgc:55602

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in retinal rod cell development. Predicted to localize to centrosome; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 67. Orthologous to human NEK2 (NIMA related kinase 2).
Genome Resources: Alliance (1),  Gene:394025 (1),  Ensembl(GRCz11):ENSDARG00000005619 (2)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:55602]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028207Tg Transgenic Insertion Unknown Unknown DNA
sa6622 Point Mutation Unknown Premature Stop ENU
sa14846 Point Mutation Unknown Premature Stop ENU
sa36991 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nek2 N/A 1
    DISEASE ASSOCIATED WITH nek2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    retinitis pigmentosa 67 Alliance ?Retinitis pigmentosa 67 615565
    DISEASE ASSOCIATED WITH nek2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process retinal rod cell development (more)
    Cellular Component centrosome (more)
    Molecular Function ATP binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nek2-201 (1)    Ensembl 1993
    nek2-202 (1)    Ensembl 858
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nek2 No data available
    MARKER RELATIONSHIPS
    nek2 Contained in: [BAC] DKEY-30H14 (order this), DKEY-249P7 (order this)
    nek2 Encodes: [cDNA] MGC:55602 (1), MGC:191706 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_201050 (1) 1998 nt
    Genomic GenBank:BX248403 (1) 154669 nt
    Select Tool
    Polypeptide UniProtKB:Q7ZUN2 (1) 440 aa
    Sequence Information (all 14)
    ORTHOLOGY for nek2 ( Chr: 20 )
    CITATIONS (24)