ZFIN is now using GRCz12tu for Genomic Data
Gene
scn1laa
- ID
- ZDB-GENE-040426-751
- Name
- sodium channel, voltage-gated, type I-like, alpha
- Symbol
- scn1laa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Contributes to voltage-gated sodium channel activity. Predicted to be involved in several processes, including membrane depolarization during action potential; neuronal action potential; and sodium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in axon. Is expressed in heart; nervous system; and neural tube. Used to study Dravet syndrome. Human ortholog(s) of this gene implicated in Dravet syndrome; developmental and epileptic encephalopathy 6B; familial hemiplegic migraine 3; generalized epilepsy with febrile seizures plus; and generalized epilepsy with febrile seizures plus 2. Orthologous to several human genes including SCN7A (sodium voltage-gated channel alpha subunit 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:55600 (6 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| developmental and epileptic encephalopathy 6B | Alliance | Developmental and epileptic encephalopathy 6B, non-Dravet | 619317 |
| Dravet syndrome | Alliance | Dravet syndrome | 607208 |
| familial hemiplegic migraine 3 | Alliance | Migraine, familial hemiplegic, 3 | 609634 |
| generalized epilepsy with febrile seizures plus 2 | Alliance | Febrile seizures, familial, 3A | 604403 |
| generalized epilepsy with febrile seizures plus 2 | Alliance | Generalized epilepsy with febrile seizures plus, type 2 | 604403 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Dravet syndrome | scn1laasa1674/sa1674 (TL) | control | Griffin et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR010526 | Sodium ion transport-associated domain |
| Domain | IPR024583 | Voltage-gated Na+ ion channel, cytoplasmic domain |
| Domain | IPR044564 | Voltage-gated sodium channel alpha subunit, inactivation gate |
| Family | IPR001696 | Voltage gated sodium channel, alpha subunit |
| Family | IPR043203 | Voltage-gated cation channel calcium and sodium |
| Homologous_superfamily | IPR027359 | Voltage-dependent channel domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Ion transport domain | Sodium ion transport-associated domain | Voltage-dependent channel domain superfamily | Voltage-gated cation channel calcium and sodium | Voltage-gated Na+ ion channel, cytoplasmic domain | Voltage gated sodium channel, alpha subunit | Voltage-gated sodium channel alpha subunit, inactivation gate |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q20JQ9 | InterPro | 1955 | |||||||
| UniProtKB:A0A0R4IUM7 | InterPro | 1955 | |||||||
| UniProtKB:A0AB32TV97 | InterPro | 1832 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
scn1laa-201
(1)
|
Ensembl | 1,053 nt | ||
| mRNA |
scn1laa-203
(1)
|
Ensembl | 6,421 nt | ||
| mRNA |
scn1laa-204
(1)
|
Ensembl | 1,255 nt | ||
| mRNA |
scn1laa-205
(1)
|
Ensembl | 2,501 nt | ||
| mRNA |
scn1laa-206
(1)
|
Ensembl | 5,868 nt | ||
| ncRNA |
ottdart00000052047
(1)
|
Ensembl | 697 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers