ZFIN ID: ZDB-GENE-040426-751
Gene Name: sodium channel, voltage-gated, type I-like, alpha
Gene Symbol: scn1laa    Nomenclature History

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Previous Names: scn1a, scn1Laa (1), zscn8 (1), Nav1.1 (1), unm_sa1674, zgc:158596, zgc:55600

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Contributes to voltage-gated sodium channel activity. Predicted to be involved in membrane depolarization during action potential; neuronal action potential; and sodium ion transmembrane transport. Predicted to localize to axon and voltage-gated sodium channel complex. Is expressed in heart; nervous system; and neural tube. Used to study Dravet syndrome. Human ortholog(s) of this gene implicated in epilepsy (multiple); erythromelalgia; familial hemiplegic migraine 3; and paroxysmal extreme pain disorder. Orthologous to several human genes including SCN1A (sodium voltage-gated channel alpha subunit 1).
Genome Resources: Alliance (1),  Gene:393101 (1),  Ensembl(GRCz11):ENSDARG00000086819 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029626Tg Transgenic Insertion Unknown Unknown DNA
sa1674 Point Mutation Unknown Missense, Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7636 Point Mutation Unknown Missense ENU
    sa15331 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21602 Point Mutation Unknown Missense, Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21603 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41553 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-scn1laa N/A 2
    MO2-scn1laa N/A 1
    DISEASE ASSOCIATED WITH scn1laa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Dravet syndrome Alliance Epileptic encephalopathy, early infantile, 6 (Dravet syndrome) 607208
    familial hemiplegic migraine 3 Alliance Migraine, familial hemiplegic, 3 609634
    generalized epilepsy with febrile seizures plus 2 Alliance Epilepsy, generalized, with febrile seizures plus, type 2 604403
    Febrile seizures, familial, 3A 604403
    DISEASE ASSOCIATED WITH scn1laa VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Dravet syndrome scn1laasa1674/sa1674 control Griffin et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component voltage-gated sodium channel complex (more)
    Molecular Function CONTRIBUTES_TO   voltage-gated sodium channel activity (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA scn1laa-201 (1)    Ensembl 1053
    scn1laa-203 (1)    Ensembl 6421
    scn1laa-204 (1)    Ensembl 1255
    ncRNA ottdart00000052047 (1)    Ensembl 697
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM scn1laa No data available
    MARKER RELATIONSHIPS
    scn1laa Contained in: [BAC] CH211-66E19 (1), CH211-120F14 (1)
    [Fosmid] CH1073-162M7 (1)
    scn1laa Encodes: [cDNA] MGC:55600 (1), MGC:158596 (1), MGC:165418 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_200132 (1) 5868 nt
    Genomic GenBank:AL929294 (1) 162474 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IUM7 (1) 1955 aa
    Sequence Information (all 28)
    ORTHOLOGY for scn1laa ( Chr: 9 )
    CITATIONS (33)